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The Roles of Endoplasmic Reticulum in NLRP3 Inflammasome Activation

College of Animal Science, Southwest University, Chongqing 402460, China
Immunology Research Center, Medical Research Institute, Southwest University, Chongqing, China
State Key Laboratories for Agrobiotechnology, Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China
Author to whom correspondence should be addressed.
Cells 2020, 9(5), 1219;
Received: 3 April 2020 / Revised: 11 May 2020 / Accepted: 13 May 2020 / Published: 14 May 2020
(This article belongs to the Special Issue Regulation of Cytokine Signaling in Immunity)
The NLRP3 (nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-containing 3) inflammasome senses pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs), and activates caspase-1, which provokes release of proinflammatory cytokines such as interleukin-1β (IL-1β) and IL-18 as well as pyroptosis to engage in innate immune defense. The endoplasmic reticulum (ER) is a large and dynamic endomembrane compartment, critical to cellular function of organelle networks. Recent studies have unveiled the pivotal roles of the ER in NLRP3 inflammasome activation. ER–mitochondria contact sites provide a location for NLRP3 activation, its association with ligands released from or residing in mitochondria, and rapid Ca2+ mobilization from ER stores to mitochondria. ER-stress signaling plays a critical role in NLRP3 inflammasome activation. Lipid perturbation and cholesterol trafficking to the ER activate the NLRP3 inflammasome. These findings emphasize the importance of the ER in initiation and regulation of the NLRP3 inflammasome. View Full-Text
Keywords: endoplasmic reticulum; NLRP3; inflammasome; IRE1α endoplasmic reticulum; NLRP3; inflammasome; IRE1α
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MDPI and ACS Style

Zhou, Y.; Tong, Z.; Jiang, S.; Zheng, W.; Zhao, J.; Zhou, X. The Roles of Endoplasmic Reticulum in NLRP3 Inflammasome Activation. Cells 2020, 9, 1219.

AMA Style

Zhou Y, Tong Z, Jiang S, Zheng W, Zhao J, Zhou X. The Roles of Endoplasmic Reticulum in NLRP3 Inflammasome Activation. Cells. 2020; 9(5):1219.

Chicago/Turabian Style

Zhou, Yang, Zhizi Tong, Songhong Jiang, Wenyan Zheng, Jianjun Zhao, and Xiangmei Zhou. 2020. "The Roles of Endoplasmic Reticulum in NLRP3 Inflammasome Activation" Cells 9, no. 5: 1219.

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