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Review

Mitophagy in the Pathogenesis of Liver Diseases †

by 1,2,3
1
Department of Biochemistry & Molecular Biology and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan
2
Liver Research Center, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan
3
Division of Allergy, Immunology, and Rheumatology, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan
Running Title: Mitophagy and Liver Diseases.
Cells 2020, 9(4), 831; https://doi.org/10.3390/cells9040831
Received: 3 March 2020 / Revised: 25 March 2020 / Accepted: 27 March 2020 / Published: 30 March 2020
Autophagy is a catabolic process involving vacuolar sequestration of intracellular components and their targeting to lysosomes for degradation, thus supporting nutrient recycling and energy regeneration. Accumulating evidence indicates that in addition to being a bulk, nonselective degradation mechanism, autophagy may selectively eliminate damaged mitochondria to promote mitochondrial turnover, a process termed “mitophagy”. Mitophagy sequesters dysfunctional mitochondria via ubiquitination and cargo receptor recognition and has emerged as an important event in the regulation of liver physiology. Recent studies have shown that mitophagy may participate in the pathogenesis of various liver diseases, such as liver injury, liver steatosis/fatty liver disease, hepatocellular carcinoma, viral hepatitis, and hepatic fibrosis. This review summarizes the current knowledge on the molecular regulations and functions of mitophagy in liver physiology and the roles of mitophagy in the development of liver-related diseases. Furthermore, the therapeutic implications of targeting hepatic mitophagy to design a new strategy to cure liver diseases are discussed. View Full-Text
Keywords: autophagy; mitophagy; liver disease; liver injury; hepatitis; steatosis; fibrosis; hepatocellular carcinoma autophagy; mitophagy; liver disease; liver injury; hepatitis; steatosis; fibrosis; hepatocellular carcinoma
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MDPI and ACS Style

Ke, P.-Y. Mitophagy in the Pathogenesis of Liver Diseases. Cells 2020, 9, 831. https://doi.org/10.3390/cells9040831

AMA Style

Ke P-Y. Mitophagy in the Pathogenesis of Liver Diseases. Cells. 2020; 9(4):831. https://doi.org/10.3390/cells9040831

Chicago/Turabian Style

Ke, Po-Yuan. 2020. "Mitophagy in the Pathogenesis of Liver Diseases" Cells 9, no. 4: 831. https://doi.org/10.3390/cells9040831

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