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Open AccessReview

Breakthrough Technologies Reshape the Ewing Sarcoma Molecular Landscape

Institute of Biomedicine of Sevilla (IBiS), Virgen del Rocio University Hospital/CSIC/University of Sevilla/CIBERONC, 41013 Seville, Spain
Department of Normal and Pathological Cytology and Histology, School of Medicine, University of Seville, 41009 Seville, Spain
Author to whom correspondence should be addressed.
All Authors contributed equally.
Cells 2020, 9(4), 804;
Received: 27 February 2020 / Revised: 21 March 2020 / Accepted: 24 March 2020 / Published: 26 March 2020
(This article belongs to the Special Issue Molecular and Cellular Mechanisms of Cancers: Bone Sarcomas)
Ewing sarcoma is a highly aggressive round cell mesenchymal neoplasm, most often occurring in children and young adults. At the molecular level, it is characterized by the presence of recurrent chromosomal translocations. In the last years, next-generation technologies have contributed to a more accurate diagnosis and a refined classification. Moreover, the application of these novel technologies has highlighted the relevance of intertumoral and intratumoral molecular heterogeneity and secondary genetic alterations. Furthermore, they have shown evidence that genomic features can change as the tumor disseminates and are influenced by treatment as well. Similarly, next-generation technologies applied to liquid biopsies will significantly impact patient management by allowing the early detection of relapse and monitoring response to treatment. Finally, the use of these novel technologies has provided data of great value in order to discover new druggable pathways. Thus, this review provides concise updates on the latest progress of these breakthrough technologies, underscoring their importance in the generation of key knowledge, prognosis, and potential treatment of Ewing Sarcoma. View Full-Text
Keywords: sarcoma; Ewing sarcoma; GF; extracellular vesicles; circulating tumor DNA/RNA; DNA repair; breakthrough technologies; mutations sarcoma; Ewing sarcoma; GF; extracellular vesicles; circulating tumor DNA/RNA; DNA repair; breakthrough technologies; mutations
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MDPI and ACS Style

Salguero-Aranda, C.; Amaral, A.T.; Olmedo-Pelayo, J.; Diaz-Martin, J.; Álava, E. Breakthrough Technologies Reshape the Ewing Sarcoma Molecular Landscape. Cells 2020, 9, 804.

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