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Open AccessFeature PaperReview

Gut–Liver Axis and Inflammasome Activation in Cholangiocyte Pathophysiology

Department of Gastroenterology and Hepatology, Università Politecnica delle Marche, 60126 Ancona, Italy
Author to whom correspondence should be addressed.
Cells 2020, 9(3), 736;
Received: 14 February 2020 / Revised: 10 March 2020 / Accepted: 13 March 2020 / Published: 17 March 2020
The Nlrp3 inflammasome is a multiprotein complex activated by a number of bacterial products or danger signals and is involved in the regulation of inflammatory processes through caspase-1 activation. The Nlrp3 is expressed in immune cells but also in hepatocytes and cholangiocytes, where it appears to be involved in regulation of biliary damage, epithelial barrier integrity and development of fibrosis. Activation of the pathways of innate immunity is crucial in the pathophysiology of hepatobiliary diseases, given the strong link between the gut and the liver. The liver secretes bile acids, which influence the bacterial composition of the gut microbiota and, in turn, are heavily modified by microbial metabolism. Alterations of this balance, as for the development of dysbiosis, may deeply influence the composition of the bacterial products that reach the liver and are able to activate a number of intracellular pathways. This alteration may be particularly important in the pathogenesis of cholangiopathies and, in particular, of primary sclerosing cholangitis, given its strong association with inflammatory bowel disease. In the present review, we summarize current knowledge on the gut–liver axis in cholangiopathies and discuss the role of Nlrp3 inflammasome activation in cholestatic conditions. View Full-Text
Keywords: inflammasome; NLRP3; cholangiocyte; gut–liver axis inflammasome; NLRP3; cholangiocyte; gut–liver axis
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MDPI and ACS Style

Maroni, L.; Ninfole, E.; Pinto, C.; Benedetti, A.; Marzioni, M. Gut–Liver Axis and Inflammasome Activation in Cholangiocyte Pathophysiology. Cells 2020, 9, 736.

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