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Review

Ovarian Cancer, Cancer Stem Cells and Current Treatment Strategies: A Potential Role of Magmas in the Current Treatment Methods

1
Fiona Elsey Cancer Research Institute, Ballarat, Victoria 3353, Australia
2
Federation University Australia, Ballarat, Victoria 3353, Australia
3
Centre for Reproductive Health, Hudson Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia
4
Department of Obstetrics and Gyanecology, University of Melbourne, Parkville, Victoria 3050, Australia
5
Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
*
Author to whom correspondence should be addressed.
Cells 2020, 9(3), 719; https://doi.org/10.3390/cells9030719
Received: 24 December 2019 / Revised: 1 March 2020 / Accepted: 6 March 2020 / Published: 14 March 2020
(This article belongs to the Special Issue Cancer Stem Cells and Resistance to Therapy)
Epithelial ovarian cancer (EOC) constitutes 90% of ovarian cancers (OC) and is the eighth most common cause of cancer-related death in women. The cancer histologically and genetically is very complex having a high degree of tumour heterogeneity. The pathogenic variability in OC causes significant impediments in effectively treating patients, resulting in a dismal prognosis. Disease progression is predominantly influenced by the peritoneal tumour microenvironment rather than properties of the tumor and is the major contributor to prognosis. Standard treatment of OC patients consists of debulking surgery, followed by chemotherapy, which in most cases end in recurrent chemoresistant disease. This review discusses the different origins of high-grade serous ovarian cancer (HGSOC), the major sub-type of EOC. Tumour heterogeneity, genetic/epigenetic changes, and cancer stem cells (CSC) in facilitating HGSOC progression and their contribution in the circumvention of therapy treatments are included. Several new treatment strategies are discussed including our preliminary proof of concept study describing the role of mitochondria-associated granulocyte macrophage colony-stimulating factor signaling protein (Magmas) in HGSOC and its unique potential role in chemotherapy-resistant disease. View Full-Text
Keywords: ovarian cancer; treatment; magmas ovarian cancer; treatment; magmas
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MDPI and ACS Style

Ahmed, N.; Kadife, E.; Raza, A.; Short, M.; Jubinsky, P.T.; Kannourakis, G. Ovarian Cancer, Cancer Stem Cells and Current Treatment Strategies: A Potential Role of Magmas in the Current Treatment Methods. Cells 2020, 9, 719. https://doi.org/10.3390/cells9030719

AMA Style

Ahmed N, Kadife E, Raza A, Short M, Jubinsky PT, Kannourakis G. Ovarian Cancer, Cancer Stem Cells and Current Treatment Strategies: A Potential Role of Magmas in the Current Treatment Methods. Cells. 2020; 9(3):719. https://doi.org/10.3390/cells9030719

Chicago/Turabian Style

Ahmed, Nuzhat; Kadife, Elif; Raza, Ali; Short, Mary; Jubinsky, Paul T.; Kannourakis, George. 2020. "Ovarian Cancer, Cancer Stem Cells and Current Treatment Strategies: A Potential Role of Magmas in the Current Treatment Methods" Cells 9, no. 3: 719. https://doi.org/10.3390/cells9030719

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