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Open AccessArticle

Mitochondria in the Nuclei of Rat Myocardial Cells

A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia
Department of Reproduction Management, Leibniz-Institute for Zoo and Wildlife Research, Alfred-Kowalke-Str. 17, 10315 Berlin, Germany
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia
Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119992 Moscow, Russia
Author to whom correspondence should be addressed.
Cells 2020, 9(3), 712;
Received: 12 December 2019 / Revised: 3 March 2020 / Accepted: 5 March 2020 / Published: 14 March 2020
(This article belongs to the Special Issue Mitochondria in Health and Diseases)
Electron microscopic study of cardiomyocytes taken from healthy Wistar and OXYS rats and naked mole rats (Heterocephalus glaber) revealed mitochondria in nuclei that lacked part of the nuclear envelope. The direct interaction of mitochondria with nucleoplasm is shown. The statistical analysis of the occurrence of mitochondria in cardiomyocyte nuclei showed that the percentage of nuclei with mitochondria was roughly around 1%, and did not show age and species dependency. Confocal microscopy of normal rat cardiac myocytes revealed a branched mitochondrial network in the vicinity of nuclei with an organization different than that of interfibrillar mitochondria. This mitochondrial network was energetically functional because it carried the membrane potential that responded by oscillatory mode after photodynamic challenge. We suggest that the presence of functional mitochondria in the nucleus is not only a consequence of certain pathologies but rather represents a normal biological phenomenon involved in mitochondrial/nuclear interactions. View Full-Text
Keywords: intranuclear mitochondria; healthy cells; electron and confocal microscopy; heart intranuclear mitochondria; healthy cells; electron and confocal microscopy; heart
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Eldarov, C.M.; Vangely, I.M.; Vays, V.B.; Sheval, E.V.; Holtze, S.; Hildebrandt, T.B.; Kolosova, N.G.; Popkov, V.A.; Plotnikov, E.Y.; Zorov, D.B.; Bakeeva, L.E.; Skulachev, V.P. Mitochondria in the Nuclei of Rat Myocardial Cells. Cells 2020, 9, 712.

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