Next Article in Journal
Nanosphere Loaded With Curcumin Inhibits the Gastrointestinal Cell Death Signaling Pathway Induced by the Foodborne Pathogen Vibrio vulnificus
Next Article in Special Issue
The Intersection of Serine Metabolism and Cellular Dysfunction in Retinal Degeneration
Previous Article in Journal
Targeting the Human 80S Ribosome in Cancer: From Structure to Function and Drug Design for Innovative Adjuvant Therapeutic Strategies
Previous Article in Special Issue
Role of FGF and Hyaluronan in Choroidal Neovascularization in Sorsby Fundus Dystrophy
Article

Innate and Autoimmunity in the Pathogenesis of Inherited Retinal Dystrophy

1
Hamilton Eye Institute, Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
2
Department of Optometry and Vision Science, University of Alabama at Birmingham, Birmingham, AL 35294, USA
3
Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
*
Author to whom correspondence should be addressed.
Cells 2020, 9(3), 630; https://doi.org/10.3390/cells9030630
Received: 28 January 2020 / Revised: 26 February 2020 / Accepted: 3 March 2020 / Published: 5 March 2020
(This article belongs to the Special Issue The Molecular and Cellular Basis of Retinal Diseases)
Inherited retinal dystrophies (RDs) are heterogenous in many aspects including genes involved, age of onset, rate of progression, and treatments. While RDs are caused by a plethora of different mutations, all result in the same outcome of blindness. While treatments, both gene therapy-based and drug-based, have been developed to slow or halt disease progression and prevent further blindness, only a small handful of the forms of RDs have treatments available, which are primarily for recessively inherited forms. Using immunohistochemical methods coupled with electroretinography, optical coherence tomography, and fluorescein angiography, we show that in rhodopsin mutant mice, the involvement of both the innate and the autoimmune systems could be a strong contributing factor in disease progression and pathogenesis. Herein, we show that monocytic phagocytosis and inflammatory cytokine release along with protein citrullination, a major player in forms of autoimmunity, work to enhance the progression of RD associated with a rhodopsin mutation. View Full-Text
Keywords: retinal degeneration; immunity; autoimmunity; rhodopsin; citrullination; retinitis pigmentosa retinal degeneration; immunity; autoimmunity; rhodopsin; citrullination; retinitis pigmentosa
Show Figures

Figure 1

MDPI and ACS Style

Hollingsworth, T.J.; Gross, A.K. Innate and Autoimmunity in the Pathogenesis of Inherited Retinal Dystrophy. Cells 2020, 9, 630. https://doi.org/10.3390/cells9030630

AMA Style

Hollingsworth TJ, Gross AK. Innate and Autoimmunity in the Pathogenesis of Inherited Retinal Dystrophy. Cells. 2020; 9(3):630. https://doi.org/10.3390/cells9030630

Chicago/Turabian Style

Hollingsworth, T. J., and Alecia K. Gross 2020. "Innate and Autoimmunity in the Pathogenesis of Inherited Retinal Dystrophy" Cells 9, no. 3: 630. https://doi.org/10.3390/cells9030630

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop