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Open AccessFeature PaperReview

Potential Applications of Extracellular Vesicles in Solid Organ Transplantation

1
Department of Medical Sciences, University of Turin, 10126 Turin, Italy
2
Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy
3
SOD Nefrologia, Dialisi e Trapianto Rene, AOU Ospedali Riuniti, 60126 Ancona, Italy
*
Author to whom correspondence should be addressed.
Cells 2020, 9(2), 369; https://doi.org/10.3390/cells9020369
Received: 17 December 2019 / Revised: 30 January 2020 / Accepted: 5 February 2020 / Published: 5 February 2020
(This article belongs to the Special Issue Therapeutic Applications of Extracellular Vesicles)
Extracellular vesicles (EVs) play an important role in cell-to-cell communication by delivering coding and non-coding RNA species and proteins to target cells. Recently, the therapeutic potential of EVs has been shown to extend to the field of solid organ transplantations. Mesenchymal stromal cell-derived EVs (MSC-EVs) in particular have been proposed as a new tool to improve graft survival, thanks to the modulation of tolerance toward the graft, and to their anti-fibrotic and pro-angiogenic effects. Moreover, MSC-EVs may reduce ischemia reperfusion injury, improving the recovery from acute damage. In addition, EVs currently considered helpful tools for preserving donor organs when administered before transplant in the context of hypothermic or normothermic perfusion machines. The addition of EVs to the perfusion solution, recently proposed for kidney, lung, and liver grafts, resulted in the amelioration of donor organ viability and functionality. EVs may therefore be of therapeutic interest in different aspects of the transplantation process for increasing the number of available organs and improving their long-term survival.
Keywords: exosomes; regenerative medicine; machinery perfusion; transplant; preconditioning exosomes; regenerative medicine; machinery perfusion; transplant; preconditioning
MDPI and ACS Style

Grange, C.; Bellucci, L.; Bussolati, B.; Ranghino, A. Potential Applications of Extracellular Vesicles in Solid Organ Transplantation. Cells 2020, 9, 369.

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