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Targeting Aggrephagy for the Treatment of Alzheimer’s Disease

1
Mr. and Mrs. Ko Chi Ming Centre for Parkinson’s Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China
2
Medical College of Acupuncture-Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
3
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
*
Author to whom correspondence should be addressed.
Cells 2020, 9(2), 311; https://doi.org/10.3390/cells9020311
Received: 1 December 2019 / Revised: 25 January 2020 / Accepted: 26 January 2020 / Published: 28 January 2020
(This article belongs to the Special Issue Advances in Selective Autophagy)
Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases in older individuals with specific neuropsychiatric symptoms. It is a proteinopathy, pathologically characterized by the presence of misfolded protein (Aβ and Tau) aggregates in the brain, causing progressive dementia. Increasing studies have provided evidence that the defect in protein-degrading systems, especially the autophagy-lysosome pathway (ALP), plays an important role in the pathogenesis of AD. Recent studies have demonstrated that AD-associated protein aggregates can be selectively recognized by some receptors and then be degraded by ALP, a process termed aggrephagy. In this study, we reviewed the role of aggrephagy in AD development and discussed the strategy of promoting aggrephagy using small molecules for the treatment of AD. View Full-Text
Keywords: aggrephagy; selective autophagy; Alzheimer’s disease; aggregates aggrephagy; selective autophagy; Alzheimer’s disease; aggregates
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MDPI and ACS Style

Malampati, S.; Song, J.-X.; Chun-Kit Tong, B.; Nalluri, A.; Yang, C.-B.; Wang, Z.; Gopalkrishnashetty Sreenivasmurthy, S.; Zhu, Z.; Liu, J.; Su, C.; Krishnamoorthi, S.; Iyaswamy, A.; Cheung, K.-H.; Lu, J.-H.; Li, M. Targeting Aggrephagy for the Treatment of Alzheimer’s Disease. Cells 2020, 9, 311. https://doi.org/10.3390/cells9020311

AMA Style

Malampati S, Song J-X, Chun-Kit Tong B, Nalluri A, Yang C-B, Wang Z, Gopalkrishnashetty Sreenivasmurthy S, Zhu Z, Liu J, Su C, Krishnamoorthi S, Iyaswamy A, Cheung K-H, Lu J-H, Li M. Targeting Aggrephagy for the Treatment of Alzheimer’s Disease. Cells. 2020; 9(2):311. https://doi.org/10.3390/cells9020311

Chicago/Turabian Style

Malampati, Sandeep, Ju-Xian Song, Benjamin Chun-Kit Tong, Anusha Nalluri, Chuan-Bin Yang, Ziying Wang, Sravan Gopalkrishnashetty Sreenivasmurthy, Zhou Zhu, Jia Liu, Chengfu Su, Senthilkumar Krishnamoorthi, Ashok Iyaswamy, King-Ho Cheung, Jia-Hong Lu, and Min Li. 2020. "Targeting Aggrephagy for the Treatment of Alzheimer’s Disease" Cells 9, no. 2: 311. https://doi.org/10.3390/cells9020311

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