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Review

Broad and Complex Roles of NBR1-Mediated Selective Autophagy in Plant Stress Responses

by 1,2 and 2,*
1
Department of Landscape and Horticulture, Ecology College, Lishui University, Lishui 323000, Zhejiang, China
2
Department of Botany and Plant Pathology and Purdue Center for Plant Biology, 915 W. State Street, Purdue University, West Lafayette, IN 47907-2054, USA
*
Author to whom correspondence should be addressed.
Cells 2020, 9(12), 2562; https://doi.org/10.3390/cells9122562
Received: 15 November 2020 / Revised: 27 November 2020 / Accepted: 27 November 2020 / Published: 30 November 2020
Selective autophagy is a highly regulated degradation pathway for the removal of specific damaged or unwanted cellular components and organelles such as protein aggregates. Cargo selectivity in selective autophagy relies on the action of cargo receptors and adaptors. In mammalian cells, two structurally related proteins p62 and NBR1 act as cargo receptors for selective autophagy of ubiquitinated proteins including aggregation-prone proteins in aggrephagy. Plant NBR1 is the structural and functional homolog of mammalian p62 and NBR1. Since its first reports almost ten years ago, plant NBR1 has been well established to function as a cargo receptor for selective autophagy of stress-induced protein aggregates and play an important role in plant responses to a broad spectrum of stress conditions including heat, salt and drought. Over the past several years, important progress has been made in the discovery of specific cargo proteins of plant NBR1 and their roles in the regulation of plant heat stress memory, plant-viral interaction and special protein secretion. There is also new evidence for a possible role of NBR1 in stress-induced pexophagy, sulfur nutrient responses and abscisic acid signaling. In this review, we summarize these progresses and discuss the potential significance of NBR1-mediated selective autophagy in broad plant responses to both biotic and abiotic stresses. View Full-Text
Keywords: autophagy; NBR1; plant stress responses; selective autophagy receptor; protein aggregates; plant heat tolerance; plant virus interaction autophagy; NBR1; plant stress responses; selective autophagy receptor; protein aggregates; plant heat tolerance; plant virus interaction
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MDPI and ACS Style

Zhang, Y.; Chen, Z. Broad and Complex Roles of NBR1-Mediated Selective Autophagy in Plant Stress Responses. Cells 2020, 9, 2562. https://doi.org/10.3390/cells9122562

AMA Style

Zhang Y, Chen Z. Broad and Complex Roles of NBR1-Mediated Selective Autophagy in Plant Stress Responses. Cells. 2020; 9(12):2562. https://doi.org/10.3390/cells9122562

Chicago/Turabian Style

Zhang, Yan, and Zhixiang Chen. 2020. "Broad and Complex Roles of NBR1-Mediated Selective Autophagy in Plant Stress Responses" Cells 9, no. 12: 2562. https://doi.org/10.3390/cells9122562

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