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Host Calcium Channels and Pumps in Viral Infections

by 1,2, 2,* and 2,*
Institute of Medical Research, Northwestern Polytechnical University, Xi’an 710072, China
National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
Authors to whom correspondence should be addressed.
Cells 2020, 9(1), 94;
Received: 11 December 2019 / Revised: 23 December 2019 / Accepted: 24 December 2019 / Published: 30 December 2019
(This article belongs to the Special Issue Cell Biology of Viral Infections)
Ca2+ is essential for virus entry, viral gene replication, virion maturation, and release. The alteration of host cells Ca2+ homeostasis is one of the strategies that viruses use to modulate host cells signal transduction mechanisms in their favor. Host calcium-permeable channels and pumps (including voltage-gated calcium channels, store-operated channels, receptor-operated channels, transient receptor potential ion channels, and Ca2+-ATPase) mediate Ca2+ across the plasma membrane or subcellular organelles, modulating intracellular free Ca2+. Therefore, these Ca2+ channels or pumps present important aspects of viral pathogenesis and virus–host interaction. It has been reported that viruses hijack host calcium channels or pumps, disturbing the cellular homeostatic balance of Ca2+. Such a disturbance benefits virus lifecycles while inducing host cells’ morbidity. Evidence has emerged that pharmacologically targeting the calcium channel or calcium release from the endoplasmic reticulum (ER) can obstruct virus lifecycles. Impeding virus-induced abnormal intracellular Ca2+ homeostasis is becoming a useful strategy in the development of potent antiviral drugs. In this present review, the recent identified cellular calcium channels and pumps as targets for virus attack are emphasized. View Full-Text
Keywords: virus; calcium channels; calcium pumps; virus–host interaction; antiviral virus; calcium channels; calcium pumps; virus–host interaction; antiviral
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MDPI and ACS Style

Chen, X.; Cao, R.; Zhong, W. Host Calcium Channels and Pumps in Viral Infections. Cells 2020, 9, 94.

AMA Style

Chen X, Cao R, Zhong W. Host Calcium Channels and Pumps in Viral Infections. Cells. 2020; 9(1):94.

Chicago/Turabian Style

Chen, Xingjuan, Ruiyuan Cao, and Wu Zhong. 2020. "Host Calcium Channels and Pumps in Viral Infections" Cells 9, no. 1: 94.

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