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Open AccessReview

Hypoxia-Inducible Factor-1α: The Master Regulator of Endothelial Cell Senescence in Vascular Aging

1
Departamento Biología de Sistemas, Facultad de Medicina y Ciencias de la Salud (IRYCIS), Universidad de Alcalá, Alcalá de Henares, 28805 Madrid, Spain
2
Departments of Pharmacology and Pathology, University of California San Diego, La Jolla, CA 92037, USA
3
Departamento de Biomedicina y Biotecnología, Facultad de Biología, Química y Ciencias Ambientales, Universidad de Alcalá, Alcalá de Henares, 28805 Madrid, Spain
4
Cardiovascular Research Center, Institute for Genomics and Multiscale Biology, New York, NY 10029, USA
5
Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA
6
Departamento de Genética, Fisiología y Microbiología, Facultad de Biología, Universidad Complutense de Madrid, 28040 Madrid, Spain
7
Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), 28041 Madrid, Spain
*
Authors to whom correspondence should be addressed.
These authors share senior authorship.
Cells 2020, 9(1), 195; https://doi.org/10.3390/cells9010195
Received: 20 December 2019 / Revised: 7 January 2020 / Accepted: 11 January 2020 / Published: 13 January 2020
Aging is one of the hottest topics in biomedical research. Advances in research and medicine have helped to preserve human health, leading to an extension of life expectancy. However, the extension of life is an irreversible process that is accompanied by the development of aging-related conditions such as weakness, slower metabolism, and stiffness of vessels. It also debated that aging can be considered an actual disease with aging-derived comorbidities, including cancer or cardiovascular disease. Currently, cardiovascular disorders, including atherosclerosis, are considered as premature aging and represent the first causes of death in developed countries, accounting for 31% of annual deaths globally. Emerging evidence has identified hypoxia-inducible factor-1α as a critical transcription factor with an essential role in aging-related pathology, in particular, regulating cellular senescence associated with cardiovascular aging. In this review, we will focus on the regulation of senescence mediated by hypoxia-inducible factor-1α in age-related pathologies, with particular emphasis on the crosstalk between endothelial and vascular cells in age-associated atherosclerotic lesions. More specifically, we will focus on the characteristics and mechanisms by which cells within the vascular wall, including endothelial and vascular cells, achieve a senescent phenotype. View Full-Text
Keywords: hypoxia-inducible factor-1α (HIF1α); vascular aging; senescent cells; endothelial cells; vascular smooth muscle cells; atherosclerosis; extracellular vesicles hypoxia-inducible factor-1α (HIF1α); vascular aging; senescent cells; endothelial cells; vascular smooth muscle cells; atherosclerosis; extracellular vesicles
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MDPI and ACS Style

Alique, M.; Sánchez-López, E.; Bodega, G.; Giannarelli, C.; Carracedo, J.; Ramírez, R. Hypoxia-Inducible Factor-1α: The Master Regulator of Endothelial Cell Senescence in Vascular Aging. Cells 2020, 9, 195.

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