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Review

The Role of Stiffness in Cell Reprogramming: A Potential Role for Biomaterials in Inducing Tissue Regeneration

Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
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Author to whom correspondence should be addressed.
Cells 2019, 8(9), 1036; https://doi.org/10.3390/cells8091036
Received: 1 July 2019 / Revised: 30 August 2019 / Accepted: 4 September 2019 / Published: 5 September 2019
The mechanotransduction is the process by which cells sense mechanical stimuli such as elasticity, viscosity, and nanotopography of extracellular matrix and translate them into biochemical signals. The mechanotransduction regulates several aspects of the cell behavior, including migration, proliferation, and differentiation in a time-dependent manner. Several reports have indicated that cell behavior and fate are not transmitted by a single signal, but rather by an intricate network of many signals operating on different length and timescales that determine cell fate. Since cell biology and biomaterial technology are fundamentals in cell-based regenerative therapies, comprehending the interaction between cells and biomaterials may allow the design of new biomaterials for clinical therapeutic applications in tissue regeneration. In this work, we present the most relevant mechanism by which the biomechanical properties of extracellular matrix (ECM) influence cell reprogramming, with particular attention on the new technologies and materials engineering, in which are taken into account not only the biochemical and biophysical signals patterns but also the factor time. View Full-Text
Keywords: mechanotransduction; biomaterials; stiffness mechanotransduction; biomaterials; stiffness
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MDPI and ACS Style

d’Angelo, M.; Benedetti, E.; Tupone, M.G.; Catanesi, M.; Castelli, V.; Antonosante, A.; Cimini, A. The Role of Stiffness in Cell Reprogramming: A Potential Role for Biomaterials in Inducing Tissue Regeneration. Cells 2019, 8, 1036. https://doi.org/10.3390/cells8091036

AMA Style

d’Angelo M, Benedetti E, Tupone MG, Catanesi M, Castelli V, Antonosante A, Cimini A. The Role of Stiffness in Cell Reprogramming: A Potential Role for Biomaterials in Inducing Tissue Regeneration. Cells. 2019; 8(9):1036. https://doi.org/10.3390/cells8091036

Chicago/Turabian Style

d’Angelo, Michele, Elisabetta Benedetti, Maria G. Tupone, Mariano Catanesi, Vanessa Castelli, Andrea Antonosante, and Annamaria Cimini. 2019. "The Role of Stiffness in Cell Reprogramming: A Potential Role for Biomaterials in Inducing Tissue Regeneration" Cells 8, no. 9: 1036. https://doi.org/10.3390/cells8091036

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