Genetic Variation Underpinning ADHD Risk in a Caribbean Community
AbstractAttention Deficit Hyperactivity Disorder (ADHD) is a highly heritable and prevalent neurodevelopmental disorder that frequently persists into adulthood. Strong evidence from genetic studies indicates that single nucleotide polymorphisms (SNPs) harboured in the ADGRL3 (LPHN3), SNAP25, FGF1, DRD4, and SLC6A2 genes are associated with ADHD. We genotyped 26 SNPs harboured in genes previously reported to be associated with ADHD and evaluated their potential association in 386 individuals belonging to 113 nuclear families from a Caribbean community in Barranquilla, Colombia, using family-based association tests. SNPs rs362990-SNAP25 (T allele; p = 2.46 × 10−4), rs2282794-FGF1 (A allele; p = 1.33 × 10−2), rs2122642-ADGRL3 (C allele, p = 3.5 × 10−2), and ADGRL3 haplotype CCC (markers rs1565902-rs10001410-rs2122642, OR = 1.74, Ppermuted = 0.021) were significantly associated with ADHD. Our results confirm the susceptibility to ADHD conferred by SNAP25, FGF1, and ADGRL3 variants in a community with a significant African American component, and provide evidence supporting the existence of specific patterns of genetic stratification underpinning the susceptibility to ADHD. Knowledge of population genetics is crucial to define risk and predict susceptibility to disease. View Full-Text
- Supplementary File 1:
PDF-Document (PDF, 698 KB)
Share & Cite This Article
Puentes-Rozo, P.J.; Acosta-López, J.E.; Cervantes-Henríquez, M.L.; Martínez-Banfi, M.L.; Mejia-Segura, E.; Sánchez-Rojas, M.; Anaya-Romero, M.E.; Acosta-Hoyos, A.; García-Llinás, G.A.; Mastronardi, C.A.; Pineda, D.A.; Castellanos, F.X.; Arcos-Burgos, M.; Vélez, J.I. Genetic Variation Underpinning ADHD Risk in a Caribbean Community. Cells 2019, 8, 907.
Puentes-Rozo PJ, Acosta-López JE, Cervantes-Henríquez ML, Martínez-Banfi ML, Mejia-Segura E, Sánchez-Rojas M, Anaya-Romero ME, Acosta-Hoyos A, García-Llinás GA, Mastronardi CA, Pineda DA, Castellanos FX, Arcos-Burgos M, Vélez JI. Genetic Variation Underpinning ADHD Risk in a Caribbean Community. Cells. 2019; 8(8):907.Chicago/Turabian Style
Puentes-Rozo, Pedro J.; Acosta-López, Johan E.; Cervantes-Henríquez, Martha L.; Martínez-Banfi, Martha L.; Mejia-Segura, Elsy; Sánchez-Rojas, Manuel; Anaya-Romero, Marco E.; Acosta-Hoyos, Antonio; García-Llinás, Guisselle A.; Mastronardi, Claudio A.; Pineda, David A.; Castellanos, F. X.; Arcos-Burgos, Mauricio; Vélez, Jorge I. 2019. "Genetic Variation Underpinning ADHD Risk in a Caribbean Community." Cells 8, no. 8: 907.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.