The Autophagy-Cilia Axis: An Intricate Relationship

Round 1

Reviewer 1 Report

The authors provide a nice review of the literature relevant to their topic- the functional connections between primary cilia and autophagy.  I have no substantive comments or suggestions.  The only error I found was in regards to section/subsection numbering.

Author Response

The error in the numbering of the sections noted by the reviewer has been corrected in the revised text.

Reviewer 2 Report

In this manuscript, Morleo and Franco reviewed recent studies on the relationship between primary cilia and autophagy. Both cilia and autophagosome are membrane surrounded structures. Emerging evidences have proved the crosstalk between these two structures. Cilia mediated signaling pathways are necessary for autophagosome formation, and conversely, autophagy regulates ciliogenesis. Although it has been reviewed multi times, this well-organized manuscript with proper and sufficient summarization will help researchers getting a more comprehensive understanding of this relationship between cilia and autophagy.

I suggest adding a figure for section 3 to 6 with genes interacting with others that localize and function in both structures.

Minor points

The headline numbers are mixed up as there two section 7 and the subtitle under section 7 are labeled as 6.x…

Author Response

The error in the numbering of the sections has been corrected in the revised text.

In addition following the reviewer suggestion a figure with the localization of the proteins of interest has been added (new figure 2). The number of the remaining figures has been changed accordingly.