Next Article in Journal
Genetic Variation Underpinning ADHD Risk in a Caribbean Community
Next Article in Special Issue
Estrogen and EGFR Pathways Regulate Notch Signaling in Opposing Directions for Multi-Ciliogenesis in the Fallopian Tube
Previous Article in Journal
Genome-Wide Identification and Characterization of Long Noncoding RNAs of Brown to White Adipose Tissue Transformation in Goats
Previous Article in Special Issue
A Ciliary View of the Immunological Synapse
Open AccessReview
Peer-Review Record

The Autophagy-Cilia Axis: An Intricate Relationship

by 1,2,* and 1,2,*
Reviewer 1: Anonymous
Reviewer 2: Quanlong Lu
Received: 19 July 2019 / Revised: 8 August 2019 / Accepted: 12 August 2019 / Published: 15 August 2019
(This article belongs to the Special Issue Cilia and Flagella: Structure, Function and Beyond)

Round 1

Reviewer 1 Report

The authors provide a nice review of the literature relevant to their topic- the functional connections between primary cilia and autophagy.  I have no substantive comments or suggestions.  The only error I found was in regards to section/subsection numbering.

Author Response

The error in the numbering of the sections noted by the reviewer has been corrected in the revised text.

Reviewer 2 Report

In this manuscript, Morleo and Franco reviewed recent studies on the relationship between primary cilia and autophagy. Both cilia and autophagosome are membrane surrounded structures. Emerging evidences have proved the crosstalk between these two structures. Cilia mediated signaling pathways are necessary for autophagosome formation, and conversely, autophagy regulates ciliogenesis. Although it has been reviewed multi times, this well-organized manuscript with proper and sufficient summarization will help researchers getting a more comprehensive understanding of this relationship between cilia and autophagy.

I suggest adding a figure for section 3 to 6 with genes interacting with others that localize and function in both structures.

Minor points

The headline numbers are mixed up as there two section 7 and the subtitle under section 7 are labeled as 6.x…

Author Response

The error in the numbering of the sections has been corrected in the revised text.


In addition following the reviewer suggestion a figure with the localization of the proteins of interest has been added (new figure 2). The number of the remaining figures has been changed accordingly.

Back to TopTop