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MicroRNAs in Obesity and Related Metabolic Disorders

Aix Marseille Univ, INSERM, INRA, C2VN, 13005 Marseille, France
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Author to whom correspondence should be addressed.
Cells 2019, 8(8), 859; https://doi.org/10.3390/cells8080859
Received: 22 July 2019 / Revised: 1 August 2019 / Accepted: 7 August 2019 / Published: 9 August 2019
(This article belongs to the Special Issue Regulatory Functions of microRNAs)
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PDF [796 KB, uploaded 9 August 2019]
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Abstract

Metabolic disorders are characterized by the inability to properly use and/or store energy. The burdens of metabolic disease, such as obesity or diabetes, are believed to arise through a complex interplay between genetics and epigenetics predisposition, environment and nutrition. Therefore, understanding the molecular mechanisms for the onset of metabolic disease will provide new insights for prevention and treatment. There is growing concern about the dysregulation of micro-RNAs (miRNAs) in metabolic diseases. MiRNAs are short non-coding RNA molecules that post-transcriptionally repress the expression of genes by binding to untranslated regions and coding sequences of the target mRNAs. This review aims to provide recent data about the potential involvement of miRNAs in metabolic diseases, particularly obesity and type 2 diabetes. View Full-Text
Keywords: micro-RNA; obesity; diabetes; adipose tissue; pancreas; inflammation; leptin micro-RNA; obesity; diabetes; adipose tissue; pancreas; inflammation; leptin
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Landrier, J.-F.; Derghal, A.; Mounien, L. MicroRNAs in Obesity and Related Metabolic Disorders. Cells 2019, 8, 859.

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