Stx5-Mediated ER-Golgi Transport in Mammals and Yeast
1
Tumor Immunology Lab, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands
2
Department of Molecular Immunology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands
*
Author to whom correspondence should be addressed.
Cells 2019, 8(8), 780; https://doi.org/10.3390/cells8080780
Received: 8 July 2019
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Revised: 25 July 2019
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Accepted: 25 July 2019
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Published: 26 July 2019
The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) syntaxin 5 (Stx5) in mammals and its ortholog Sed5p in Saccharomyces cerevisiae mediate anterograde and retrograde endoplasmic reticulum (ER)-Golgi trafficking. Stx5 and Sed5p are structurally highly conserved and are both regulated by interactions with other ER-Golgi SNARE proteins, the Sec1/Munc18-like protein Scfd1/Sly1p and the membrane tethering complexes COG, p115, and GM130. Despite these similarities, yeast Sed5p and mammalian Stx5 are differently recruited to COPII-coated vesicles, and Stx5 interacts with the microtubular cytoskeleton, whereas Sed5p does not. In this review, we argue that these different Stx5 interactions contribute to structural differences in ER-Golgi transport between mammalian and yeast cells. Insight into the function of Stx5 is important given its essential role in the secretory pathway of eukaryotic cells and its involvement in infections and neurodegenerative diseases.
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Keywords:
syntaxin 5; Golgi apparatus; endoplasmic reticulum; membrane trafficking; secretory pathway
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MDPI and ACS Style
Linders, P.T.; van der Horst, C.; ter Beest, M.; van den Bogaart, G. Stx5-Mediated ER-Golgi Transport in Mammals and Yeast. Cells 2019, 8, 780. https://doi.org/10.3390/cells8080780
AMA Style
Linders PT, van der Horst C, ter Beest M, van den Bogaart G. Stx5-Mediated ER-Golgi Transport in Mammals and Yeast. Cells. 2019; 8(8):780. https://doi.org/10.3390/cells8080780
Chicago/Turabian StyleLinders, Peter T., Chiel van der Horst, Martin ter Beest, and Geert van den Bogaart. 2019. "Stx5-Mediated ER-Golgi Transport in Mammals and Yeast" Cells 8, no. 8: 780. https://doi.org/10.3390/cells8080780
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