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Review

Role of Cardiolipin in Mitochondrial Function and Dynamics in Health and Disease: Molecular and Pharmacological Aspects

1
Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, 70125 Bari, Italy
2
Maasstad Ziekenhuis, 3079 DZ Rotterdam, The Netherlands
3
Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IBIOM), National Research Council (CNR), 70126 Bari, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Laura Riboni
Cells 2019, 8(7), 728; https://doi.org/10.3390/cells8070728
Received: 27 June 2019 / Revised: 12 July 2019 / Accepted: 14 July 2019 / Published: 16 July 2019
(This article belongs to the Special Issue Phospholipids: Dynamic Lipid Signaling in Health and Diseases)
In eukaryotic cells, mitochondria are involved in a large array of metabolic and bioenergetic processes that are vital for cell survival. Phospholipids are the main building blocks of mitochondrial membranes. Cardiolipin (CL) is a unique phospholipid which is localized and synthesized in the inner mitochondrial membrane (IMM). It is now widely accepted that CL plays a central role in many reactions and processes involved in mitochondrial function and dynamics. Cardiolipin interacts with and is required for optimal activity of several IMM proteins, including the enzyme complexes of the electron transport chain (ETC) and ATP production and for their organization into supercomplexes. Moreover, CL plays an important role in mitochondrial membrane morphology, stability and dynamics, in mitochondrial biogenesis and protein import, in mitophagy, and in different mitochondrial steps of the apoptotic process. It is conceivable that abnormalities in CL content, composition and level of oxidation may negatively impact mitochondrial function and dynamics, with important implications in a variety of pathophysiological situations and diseases. In this review, we focus on the role played by CL in mitochondrial function and dynamics in health and diseases and on the potential of pharmacological modulation of CL through several agents in attenuating mitochondrial dysfunction. View Full-Text
Keywords: Cardiolipin; mitochondrial structure-function; physiopathology; pharmacological agents Cardiolipin; mitochondrial structure-function; physiopathology; pharmacological agents
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MDPI and ACS Style

Paradies, G.; Paradies, V.; Ruggiero, F.M.; Petrosillo, G. Role of Cardiolipin in Mitochondrial Function and Dynamics in Health and Disease: Molecular and Pharmacological Aspects. Cells 2019, 8, 728. https://doi.org/10.3390/cells8070728

AMA Style

Paradies G, Paradies V, Ruggiero FM, Petrosillo G. Role of Cardiolipin in Mitochondrial Function and Dynamics in Health and Disease: Molecular and Pharmacological Aspects. Cells. 2019; 8(7):728. https://doi.org/10.3390/cells8070728

Chicago/Turabian Style

Paradies, Giuseppe, Valeria Paradies, Francesca M. Ruggiero, and Giuseppe Petrosillo. 2019. "Role of Cardiolipin in Mitochondrial Function and Dynamics in Health and Disease: Molecular and Pharmacological Aspects" Cells 8, no. 7: 728. https://doi.org/10.3390/cells8070728

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