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Mito-Nuclear Communication in Hepatocellular Carcinoma Metabolic Rewiring

1
Clinical Gastroenterology Unit, Department of Biomedical Clinical and Experimental Sciences “Mario Serio”, University of Florence, V.le Pieraccini 6, Florence 50129, Italy
2
University of Siena, 53100 Siena, Italy
*
Author to whom correspondence should be addressed.
Cells 2019, 8(5), 417; https://doi.org/10.3390/cells8050417
Received: 22 March 2019 / Revised: 29 April 2019 / Accepted: 1 May 2019 / Published: 5 May 2019
(This article belongs to the Special Issue Mitochondrial Metabolic Reprogramming and Nuclear Crosstalk in Cancer)
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Abstract

As the main metabolic and detoxification organ, the liver constantly adapts its activity to fulfill the energy requirements of the whole body. Despite the remarkable adaptive capacity of the liver, prolonged exposure to noxious stimuli such as alcohol, viruses and metabolic disorders results in the development of chronic liver disease that can progress to hepatocellular carcinoma (HCC), which is currently the second leading cause of cancer-related death worldwide. Metabolic rewiring is a common feature of cancers, including HCC. Altered mito-nuclear communication is emerging as a driving force in the metabolic reprogramming of cancer cells, affecting all aspects of cancer biology from neoplastic transformation to acquired drug resistance. Here, we explore relevant aspects (and discuss recent findings) of mito-nuclear crosstalk in the metabolic reprogramming of hepatocellular carcinoma. View Full-Text
Keywords: HCC; PPAR; SIRT; PGC-1; NRF; HIF; liver; mitochondria; metabolism HCC; PPAR; SIRT; PGC-1; NRF; HIF; liver; mitochondria; metabolism
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Mello, T.; Simeone, I.; Galli, A. Mito-Nuclear Communication in Hepatocellular Carcinoma Metabolic Rewiring. Cells 2019, 8, 417.

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