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Neuroprotection, Recovery of Function and Endogenous Neurogenesis in Traumatic Spinal Cord Injury Following Transplantation of Activated Adipose Tissue

1
Laboratory of Pharmacology, Department of Health Sciences, University of Milan, Via A. di Rudinì 8, 20142 Milan, Italy
2
Pediatric Clinical Research Center “Fondazione Romeo e Enrica Invernizzi”, University of Milan, via Giovanni Battista Grassi 74, 20142 Milan, Italy
3
Pathological Anatomy, Department of Health Science, University of Milano, Via A. di Rudini’ 8, 20142 Milano, Italy
*
Authors to whom correspondence should be addressed.
These authors equally contributed to this work.
Cells 2019, 8(4), 329; https://doi.org/10.3390/cells8040329
Received: 28 January 2019 / Revised: 1 April 2019 / Accepted: 6 April 2019 / Published: 8 April 2019
(This article belongs to the Special Issue Stem Cells and Degenerative Diseases)
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Abstract

Spinal cord injury (SCI) is a devastating disease, which leads to paralysis and is associated to substantially high costs for the individual and society. At present, no effective therapies are available. Here, the use of mechanically-activated lipoaspirate adipose tissue (MALS) in a murine experimental model of SCI is presented. Our results show that, following acute intraspinal MALS transplantation, there is an engraftment at injury site with the acute powerful inhibition of the posttraumatic inflammatory response, followed by a significant progressive improvement in recovery of function. This is accompanied by spinal cord tissue preservation at the lesion site with the promotion of endogenous neurogenesis as indicated by the significant increase of Nestin-positive cells in perilesional areas. Cells originated from MALS infiltrate profoundly the recipient cord, while the extra-dural fat transplant is gradually impoverished in stromal cells. Altogether, these novel results suggest the potential of MALS application in the promotion of recovery in SCI. View Full-Text
Keywords: spinal cord injury; adipose tissue; mechanical activation; cell therapies; inflammation; neuroprotection; neurogenesis spinal cord injury; adipose tissue; mechanical activation; cell therapies; inflammation; neuroprotection; neurogenesis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Carelli, S.; Giallongo, T.; Rey, F.; Colli, M.; Tosi, D.; Bulfamante, G.; Di Giulio, A.M.; Gorio, A. Neuroprotection, Recovery of Function and Endogenous Neurogenesis in Traumatic Spinal Cord Injury Following Transplantation of Activated Adipose Tissue. Cells 2019, 8, 329.

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