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Open AccessFeature PaperReview

Microtubular and Nuclear Functions of γ-Tubulin: Are They LINCed?

Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague, Czech Republic
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Cells 2019, 8(3), 259; https://doi.org/10.3390/cells8030259
Received: 8 February 2019 / Revised: 7 March 2019 / Accepted: 14 March 2019 / Published: 19 March 2019
(This article belongs to the Special Issue Tubulin: Structure, Functions and Roles in Disease)
γ-Tubulin is a conserved member of the tubulin superfamily with a function in microtubule nucleation. Proteins of γ-tubulin complexes serve as nucleation templates as well as a majority of other proteins contributing to centrosomal and non-centrosomal nucleation, conserved across eukaryotes. There is a growing amount of evidence of γ-tubulin functions besides microtubule nucleation in transcription, DNA damage response, chromatin remodeling, and on its interactions with tumor suppressors. However, the molecular mechanisms are not well understood. Furthermore, interactions with lamin and SUN proteins of the LINC complex suggest the role of γ-tubulin in the coupling of nuclear organization with cytoskeletons. γ-Tubulin that belongs to the clade of eukaryotic tubulins shows characteristics of both prokaryotic and eukaryotic tubulins. Both human and plant γ-tubulins preserve the ability of prokaryotic tubulins to assemble filaments and higher-order fibrillar networks. γ-Tubulin filaments, with bundling and aggregating capacity, are suggested to perform complex scaffolding and sequestration functions. In this review, we discuss a plethora of γ-tubulin molecular interactions and cellular functions, as well as recent advances in understanding the molecular mechanisms behind them. View Full-Text
Keywords: gamma-tubulin; nucleation; nuclear functions; filaments; lamins; SUN proteins; mechanosensing gamma-tubulin; nucleation; nuclear functions; filaments; lamins; SUN proteins; mechanosensing
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MDPI and ACS Style

Chumová, J.; Kourová, H.; Trögelová, L.; Halada, P.; Binarová, P. Microtubular and Nuclear Functions of γ-Tubulin: Are They LINCed? Cells 2019, 8, 259. https://doi.org/10.3390/cells8030259

AMA Style

Chumová J, Kourová H, Trögelová L, Halada P, Binarová P. Microtubular and Nuclear Functions of γ-Tubulin: Are They LINCed? Cells. 2019; 8(3):259. https://doi.org/10.3390/cells8030259

Chicago/Turabian Style

Chumová, Jana; Kourová, Hana; Trögelová, Lucie; Halada, Petr; Binarová, Pavla. 2019. "Microtubular and Nuclear Functions of γ-Tubulin: Are They LINCed?" Cells 8, no. 3: 259. https://doi.org/10.3390/cells8030259

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