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Cells 2019, 8(2), 87; https://doi.org/10.3390/cells8020087

Emerging Roles of Ephexins in Physiology and Disease

1,2,†,* , 1,†
and
1,2,*
1
School of Life Sciences and Aging Research Institute, Gwangju Institute of Science and Technology, Gwangju 61005, Korea
2
Research Center for Cellular Homeostasis, Ewha Womans University, Seoul 03760, Korea
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 26 December 2018 / Revised: 20 January 2019 / Accepted: 24 January 2019 / Published: 24 January 2019
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Abstract

Dbl (B-cell lymphoma)-related guanine nucleotide exchange factors (GEFs), the largest family of GEFs, are directly responsible for the activation of Rho family GTPases and essential for a number of cellular events such as proliferation, differentiation and movement. The members of the Ephexin (Eph-interacting exchange protein) family, a subgroup of Dbl GEFs, initially were named for their interaction with Eph receptors and sequence homology with Ephexin1. Although the first Ephexin was identified about two decades ago, their functions in physiological and pathological contexts and regulatory mechanisms remained elusive until recently. Ephexins are now considered as GEFs that can activate Rho GTPases such as RhoA, Rac, Cdc42, and RhoG. Moreover, Ephexins have been shown to have pivotal roles in neural development, tumorigenesis, and efferocytosis. In this review, we discuss the known and proposed functions of Ephexins in physiological and pathological contexts, as well as their regulatory mechanisms. View Full-Text
Keywords: Ephexin; Ephexin1; Ephexin2; Ephexin3; Ephexin4; Ephexin5; guanine nucleotide exchange factor; GEF; Dbl family; Rho GTPase Ephexin; Ephexin1; Ephexin2; Ephexin3; Ephexin4; Ephexin5; guanine nucleotide exchange factor; GEF; Dbl family; Rho GTPase
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Kim, K.; Lee, S.-A.; Park, D. Emerging Roles of Ephexins in Physiology and Disease. Cells 2019, 8, 87.

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