Next Article in Journal
Hutchinson-Gilford Progeria Syndrome—Current Status and Prospects for Gene Therapy Treatment
Previous Article in Journal
The Catalase Gene Family in Cotton: Genome-Wide Characterization and Bioinformatics Analysis
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessReview
Cells 2019, 8(2), 87;

Emerging Roles of Ephexins in Physiology and Disease

1,2,†,* , 1,†
School of Life Sciences and Aging Research Institute, Gwangju Institute of Science and Technology, Gwangju 61005, Korea
Research Center for Cellular Homeostasis, Ewha Womans University, Seoul 03760, Korea
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 26 December 2018 / Revised: 20 January 2019 / Accepted: 24 January 2019 / Published: 24 January 2019
Full-Text   |   PDF [1265 KB, uploaded 24 January 2019]   |  
  |   Review Reports


Dbl (B-cell lymphoma)-related guanine nucleotide exchange factors (GEFs), the largest family of GEFs, are directly responsible for the activation of Rho family GTPases and essential for a number of cellular events such as proliferation, differentiation and movement. The members of the Ephexin (Eph-interacting exchange protein) family, a subgroup of Dbl GEFs, initially were named for their interaction with Eph receptors and sequence homology with Ephexin1. Although the first Ephexin was identified about two decades ago, their functions in physiological and pathological contexts and regulatory mechanisms remained elusive until recently. Ephexins are now considered as GEFs that can activate Rho GTPases such as RhoA, Rac, Cdc42, and RhoG. Moreover, Ephexins have been shown to have pivotal roles in neural development, tumorigenesis, and efferocytosis. In this review, we discuss the known and proposed functions of Ephexins in physiological and pathological contexts, as well as their regulatory mechanisms. View Full-Text
Keywords: Ephexin; Ephexin1; Ephexin2; Ephexin3; Ephexin4; Ephexin5; guanine nucleotide exchange factor; GEF; Dbl family; Rho GTPase Ephexin; Ephexin1; Ephexin2; Ephexin3; Ephexin4; Ephexin5; guanine nucleotide exchange factor; GEF; Dbl family; Rho GTPase

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Kim, K.; Lee, S.-A.; Park, D. Emerging Roles of Ephexins in Physiology and Disease. Cells 2019, 8, 87.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top