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Cells
Volume 8
Issue 12
10.3390/cells8121492
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Review

MicroRNAs Involved in Carcinogenesis, Prognosis, Therapeutic Resistance, and Applications in Human Triple-Negative Breast Cancer

by
Lei Ding
1,2,†,
Huan Gu
1,2,†,
Xianhui Xiong
1,2,†,
Hongshun Ao
1,2,
Jiaqi Cao
1,2,
Wen Lin
1,2,
Min Yu
1,2,
Jie Lin
1,2 and
Qinghua Cui
1,2,*
1
Lab of Biochemistry & Molecular Biology, School of Life Sciences, Yunnan University, Kunming 650091, China
2
Key Lab of Molecular Cancer Biology, Yunnan Education Department, Kunming 650091, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Cells 2019, 8(12), 1492; https://doi.org/10.3390/cells8121492
Received: 13 October 2019 / Revised: 18 November 2019 / Accepted: 19 November 2019 / Published: 22 November 2019
(This article belongs to the Special Issue Cancer Related microRNAs)
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Abstract

Triple-negative breast cancer (TNBC) is the most aggressive, prevalent, and distinct subtype of breast cancer characterized by high recurrence rates and poor clinical prognosis, devoid of both predictive markers and potential therapeutic targets. MicroRNAs (miRNA/miR) are a family of small, endogenous, non-coding, single-stranded regulatory RNAs that bind to the 3′-untranslated region (3′-UTR) complementary sequences and downregulate the translation of target mRNAs as post-transcriptional regulators. Dysregulation miRNAs are involved in broad spectrum cellular processes of TNBC, exerting their function as oncogenes or tumor suppressors depending on their cellular target involved in tumor initiation, promotion, malignant conversion, and metastasis. In this review, we emphasize on masses of miRNAs that act as oncogenes or tumor suppressors involved in epithelial–mesenchymal transition (EMT), maintenance of stemness, tumor invasion and metastasis, cell proliferation, and apoptosis. We also discuss miRNAs as the targets or as the regulators of dysregulation epigenetic modulation in the carcinogenesis process of TNBC. Furthermore, we show that miRNAs used as potential classification, prognostic, chemotherapy and radiotherapy resistance markers in TNBC. Finally, we present the perspective on miRNA therapeutics with mimics or antagonists, and focus on the challenges of miRNA therapy. This study offers an insight into the role of miRNA in pathology progression of TNBC. View Full-Text
Keywords: triple-negative breast cancer (TNBC); miRNAs; tumorigenesis; prognosis; chemotherapy and radiotherapy resistance; therapeutic strategies; epigenetic mechanisms triple-negative breast cancer (TNBC); miRNAs; tumorigenesis; prognosis; chemotherapy and radiotherapy resistance; therapeutic strategies; epigenetic mechanisms
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
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MDPI and ACS Style

Ding, L.; Gu, H.; Xiong, X.; Ao, H.; Cao, J.; Lin, W.; Yu, M.; Lin, J.; Cui, Q. MicroRNAs Involved in Carcinogenesis, Prognosis, Therapeutic Resistance, and Applications in Human Triple-Negative Breast Cancer. Cells 2019, 8, 1492. https://doi.org/10.3390/cells8121492

AMA Style

Ding L, Gu H, Xiong X, Ao H, Cao J, Lin W, Yu M, Lin J, Cui Q. MicroRNAs Involved in Carcinogenesis, Prognosis, Therapeutic Resistance, and Applications in Human Triple-Negative Breast Cancer. Cells. 2019; 8(12):1492. https://doi.org/10.3390/cells8121492

Chicago/Turabian Style

Ding, Lei, Huan Gu, Xianhui Xiong, Hongshun Ao, Jiaqi Cao, Wen Lin, Min Yu, Jie Lin, and Qinghua Cui. 2019. "MicroRNAs Involved in Carcinogenesis, Prognosis, Therapeutic Resistance, and Applications in Human Triple-Negative Breast Cancer" Cells 8, no. 12: 1492. https://doi.org/10.3390/cells8121492

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