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The Impact of Oxidative Stress on Ribosomes: From Injury to Regulation

Department of Cell Biology and Neuroscience, Rowan University School of Osteopathic Medicine, Stratford, NJ 08084, USA
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Cells 2019, 8(11), 1379; https://doi.org/10.3390/cells8111379
Received: 27 September 2019 / Revised: 23 October 2019 / Accepted: 30 October 2019 / Published: 2 November 2019
(This article belongs to the Special Issue Ribosome Function and Dynamics)
The ribosome is a complex ribonucleoprotein-based molecular machine that orchestrates protein synthesis in the cell. Both ribosomal RNA and ribosomal proteins can be chemically modified by reactive oxygen species, which may alter the ribosome′s functions or cause a complete loss of functionality. The oxidative damage that ribosomes accumulate during their lifespan in a cell may lead to reduced or faulty translation and contribute to various pathologies. However, remarkably little is known about the biological consequences of oxidative damage to the ribosome. Here, we provide a concise summary of the known types of changes induced by reactive oxygen species in rRNA and ribosomal proteins and discuss the existing experimental evidence of how these modifications may affect ribosome dynamics and function. We emphasize the special role that redox-active transition metals, such as iron, play in ribosome homeostasis and stability. We also discuss the hypothesis that redox-mediated ribosome modifications may contribute to adaptive cellular responses to stress. View Full-Text
Keywords: ribosomal RNA (rRNA); ribosomal proteins; translation; reactive oxygen species; oxidative damage; iron homeostasis; Fenton reaction; stress response ribosomal RNA (rRNA); ribosomal proteins; translation; reactive oxygen species; oxidative damage; iron homeostasis; Fenton reaction; stress response
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Shcherbik, N.; Pestov, D.G. The Impact of Oxidative Stress on Ribosomes: From Injury to Regulation. Cells 2019, 8, 1379.

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