Next Article in Journal
Syncytiotrophoblast of Placentae from Women with Zika Virus Infection Has Altered Tight Junction Protein Expression and Increased Paracellular Permeability
Next Article in Special Issue
Update on the Role of the Non-Canonical Wnt/Planar Cell Polarity Pathway in Neural Tube Defects
Previous Article in Journal
Mitogen-Activated Protein Kinases (MAPKs) and Cholangiocarcinoma: The Missing Link
Previous Article in Special Issue
Intracellular Signals Activated by Canonical Wnt Ligands Independent of GSK3 Inhibition and β-Catenin Stabilization
Open AccessReview

Wnt Signaling in Neural Crest Ontogenesis and Oncogenesis

by Yu Ji 1,2,3,*, Hongyan Hao 3,4, Kurt Reynolds 1,2,3, Moira McMahon 2,5 and Chengji J. Zhou 1,2,3,*
Department of Biochemistry and Molecular Medicine & Comprehensive Cancer Center, University of California at Davis, School of Medicine, Sacramento, CA 95817, USA
Institute for Pediatric Regenerative Medicine, UC Davis School of Medicine and Shriners Hospitals for Children, Sacramento, CA 95817, USA
Graduate Program of Biochemistry, Molecular, Cellular and Developmental Biology, University of California, Davis, CA 95616, USA
Department of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA
College of Letters & Science, University of California, Berkeley, CA 94720, USA
Authors to whom correspondence should be addressed.
Cells 2019, 8(10), 1173;
Received: 30 August 2019 / Revised: 23 September 2019 / Accepted: 25 September 2019 / Published: 29 September 2019
(This article belongs to the Special Issue Wnt Signaling in Health and Diseases)
Neural crest (NC) cells are a temporary population of multipotent stem cells that generate a diverse array of cell types, including craniofacial bone and cartilage, smooth muscle cells, melanocytes, and peripheral neurons and glia during embryonic development. Defective neural crest development can cause severe and common structural birth defects, such as craniofacial anomalies and congenital heart disease. In the early vertebrate embryos, NC cells emerge from the dorsal edge of the neural tube during neurulation and then migrate extensively throughout the anterior-posterior body axis to generate numerous derivatives. Wnt signaling plays essential roles in embryonic development and cancer. This review summarizes current understanding of Wnt signaling in NC cell induction, delamination, migration, multipotency, and fate determination, as well as in NC-derived cancers. View Full-Text
Keywords: Wnt; neural crest stem cells; neural crest-derived cancer Wnt; neural crest stem cells; neural crest-derived cancer
Show Figures

Figure 1

MDPI and ACS Style

Ji, Y.; Hao, H.; Reynolds, K.; McMahon, M.; Zhou, C.J. Wnt Signaling in Neural Crest Ontogenesis and Oncogenesis. Cells 2019, 8, 1173.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop