Next Article in Journal
Increasing the TRPM2 Channel Expression in Human Neuroblastoma SH-SY5Y Cells Augments the Susceptibility to ROS-Induced Cell Death
Previous Article in Journal
Treatment of Parkinson’s Disease through Personalized Medicine and Induced Pluripotent Stem Cells
Previous Article in Special Issue
Zonisamide Administration Improves Fatty Acid β-Oxidation in Parkinson’s Disease
Article Menu

Export Article

Open AccessReview
Cells 2019, 8(1), 27; https://doi.org/10.3390/cells8010027

The Role of Lipids in Parkinson’s Disease

1
Department of Cell Biology, Radboud Institute for Molecular Life Sciences (RIMLS), Radboudumc, 6525 GA Nijmegen, The Netherlands
2
Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GA Nijmegen, The Netherlands
*
Author to whom correspondence should be addressed.
Received: 19 November 2018 / Accepted: 27 December 2018 / Published: 7 January 2019
(This article belongs to the Special Issue The Molecular and Cellular Basis for Parkinson's Disease)
Full-Text   |   PDF [5029 KB, uploaded 11 January 2019]   |  
  |   Review Reports

Abstract

Parkinson’s disease (PD) is a neurodegenerative disease characterized by a progressive loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and microgliosis. During the past decades multiple cellular pathways have been associated with PD pathology (i.e., oxidative stress, endosomal-lysosomal dysfunction, endoplasmic reticulum stress, and immune response), yet disease-modifying treatments are not available. We have recently used genetic data from familial and sporadic cases in an unbiased approach to build a molecular landscape for PD, revealing lipids as central players in this disease. Here we extensively review the current knowledge concerning the involvement of various subclasses of fatty acyls, glycerolipids, glycerophospholipids, sphingolipids, sterols, and lipoproteins in PD pathogenesis. Our review corroborates a central role for most lipid classes, but the available information is fragmented, not always reproducible, and sometimes differs by sex, age or PD etiology of the patients. This hinders drawing firm conclusions about causal or associative effects of dietary lipids or defects in specific steps of lipid metabolism in PD. Future technological advances in lipidomics and additional systematic studies on lipid species from PD patient material may improve this situation and lead to a better appreciation of the significance of lipids for this devastating disease. View Full-Text
Keywords: Parkinson’s disease; fatty acyls; glycerolipids; glycerophospholipids; sphingolipids; sterol lipids; lipoproteins; α-synuclein-mediated pathology; disease-modifying effects; neuroprotection Parkinson’s disease; fatty acyls; glycerolipids; glycerophospholipids; sphingolipids; sterol lipids; lipoproteins; α-synuclein-mediated pathology; disease-modifying effects; neuroprotection
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Xicoy, H.; Wieringa, B.; Martens, G.J.M. The Role of Lipids in Parkinson’s Disease. Cells 2019, 8, 27.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top