Next Article in Journal
Treatment of Parkinson’s Disease through Personalized Medicine and Induced Pluripotent Stem Cells
Previous Article in Journal
Mechanism of Siponimod: Anti-Inflammatory and Neuroprotective Mode of Action
Previous Article in Special Issue
Synthesis and Biological Evaluation of Novel Triple-Modified Colchicine Derivatives as Potent Tubulin-Targeting Anticancer Agents
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Cells 2019, 8(1), 25;

Over-Expression of βII-Tubulin and Especially Its Localization in Cell Nuclei Correlates with Poorer Outcomes in Colorectal Cancer

N.N. Alexandrov National Cancer Centre of Belarus, 223040 Minsk, Belarus
Department of Pathology, Belarusian State Medical University, 220116 Minsk, Belarus
Minsk City Clinical Oncologic Dispensary, 220013 Minsk, Belarus
Department of Gastroenterology and Nutrition, Belarusian Medical Academy of Post-Graduate Education, 220013 Minsk, Belarus
Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, TX 78229, USA
Author to whom correspondence should be addressed.
Received: 17 December 2018 / Accepted: 2 January 2019 / Published: 7 January 2019
(This article belongs to the Special Issue Tubulin: Structure, Functions and Roles in Disease)
Full-Text   |   PDF [1912 KB, uploaded 7 January 2019]   |  


Tubulin is a heterodimer of α and β subunits, both existing as isotypes differing in amino acid sequence encoded by different genes. Specific isotypes of tubulin have associations with cancer that are not well understood. Previous studies found that βII-tubulin is expressed in a number of transformed cells and that this isotype is found in cell nuclei in non-microtubule form. The association of βII expression and its nuclear localization with cancer progression has not previously been addressed. We here used a monoclonal antibody to βII to examine patients with colorectal cancer and found that patients whose tumors over-express βII have a greatly decreased life expectancy which is even shorter in those patients with nuclear βII. Our results suggest that βII-tubulin may facilitate cancer growth and metastasis and, to accomplish this, may not need to be in microtubule form. Furthermore, βII expression and localization could be a useful prognostic marker. We also found that βII appears in the nuclei of otherwise normal cells adjacent to the tumor. It is possible therefore that cancer cells expressing βII influence nearby cells to do the same and to localize βII in their nuclei by an as yet uncharacterized regulatory pathway. View Full-Text
Keywords: βII-tubulin; microtubules; nuclear tubulin; colorectal cancer; cancer prognosis βII-tubulin; microtubules; nuclear tubulin; colorectal cancer; cancer prognosis

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Ruksha, K.; Mezheyeuski, A.; Nerovnya, A.; Bich, T.; Tur, G.; Gorgun, J.; Luduena, R.; Portyanko, A. Over-Expression of βII-Tubulin and Especially Its Localization in Cell Nuclei Correlates with Poorer Outcomes in Colorectal Cancer. Cells 2019, 8, 25.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top