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Cells 2019, 8(1), 18; https://doi.org/10.3390/cells8010018

mTOR: A Cellular Regulator Interface in Health and Disease

Biochemie Intrazellulärer Transportprozesse, Ruhr-Universität Bochum, 44801 Bochum, Germany
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Received: 10 December 2018 / Revised: 25 December 2018 / Accepted: 1 January 2019 / Published: 2 January 2019
(This article belongs to the Special Issue 2018 Select Papers by Cells’ Editorial Board Members)
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Abstract

The mechanistic target of Rapamycin (mTOR) is a ubiquitously-conserved serine/threonine kinase, which has a central function in integrating growth signals and orchestrating their physiologic effects on cellular level. mTOR is the core component of differently composed signaling complexes that differ in protein composition and molecular targets. Newly identified classes of mTOR inhibitors are being developed to block autoimmune diseases and transplant rejections but also to treat obesity, diabetes, and different types of cancer. Therefore, the selective and context-dependent inhibition of mTOR activity itself might come into the focus as molecular target to prevent severe diseases and possibly to extend life span. This review provides a general introduction to the molecular composition and physiologic function of mTOR complexes as part of the Special Issue “2018 Select Papers by Cells’ Editorial Board Members”. View Full-Text
Keywords: mTOR; autophagy; kinase; phosphorylation; aging; cancer mTOR; autophagy; kinase; phosphorylation; aging; cancer
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Boutouja, F.; Stiehm, C.M.; Platta, H.W. mTOR: A Cellular Regulator Interface in Health and Disease. Cells 2019, 8, 18.

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