Cells 2018, 7(7), 79; https://doi.org/10.3390/cells7070079
Chlamydomonas Basal Bodies as Flagella Organizing Centers
Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
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Received: 12 June 2018 / Revised: 9 July 2018 / Accepted: 10 July 2018 / Published: 17 July 2018
(This article belongs to the Special Issue Comparative Biology of Centrosomal Structures in Eukaryotes)
Abstract
During ciliogenesis, centrioles convert to membrane-docked basal bodies, which initiate the formation of cilia/flagella and template the nine doublet microtubules of the flagellar axoneme. The discovery that many human diseases and developmental disorders result from defects in flagella has fueled a strong interest in the analysis of flagellar assembly. Here, we will review the structure, function, and development of basal bodies in the unicellular green alga Chlamydomonas reinhardtii, a widely used model for the analysis of basal bodies and flagella. Intraflagellar transport (IFT), a flagella-specific protein shuttle critical for ciliogenesis, was first described in C. reinhardtii. A focus of this review will be on the role of the basal bodies in organizing the IFT machinery. View Full-TextKeywords:
bld2; bld10; bld12; centrin; striated fiber assemblin (SFA); intraflagellar transport (IFT); axoneme; central pair; microtubules; centriole
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MDPI and ACS Style
Wingfield, J.L.; Lechtreck, K.-F. Chlamydomonas Basal Bodies as Flagella Organizing Centers. Cells 2018, 7, 79.
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