Chlamydomonas Basal Bodies as Flagella Organizing Centers
AbstractDuring ciliogenesis, centrioles convert to membrane-docked basal bodies, which initiate the formation of cilia/flagella and template the nine doublet microtubules of the flagellar axoneme. The discovery that many human diseases and developmental disorders result from defects in flagella has fueled a strong interest in the analysis of flagellar assembly. Here, we will review the structure, function, and development of basal bodies in the unicellular green alga Chlamydomonas reinhardtii, a widely used model for the analysis of basal bodies and flagella. Intraflagellar transport (IFT), a flagella-specific protein shuttle critical for ciliogenesis, was first described in C. reinhardtii. A focus of this review will be on the role of the basal bodies in organizing the IFT machinery. View Full-Text
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Wingfield, J.L.; Lechtreck, K.-F. Chlamydomonas Basal Bodies as Flagella Organizing Centers. Cells 2018, 7, 79.
Wingfield JL, Lechtreck K-F. Chlamydomonas Basal Bodies as Flagella Organizing Centers. Cells. 2018; 7(7):79.Chicago/Turabian Style
Wingfield, Jenna L.; Lechtreck, Karl-Ferdinand. 2018. "Chlamydomonas Basal Bodies as Flagella Organizing Centers." Cells 7, no. 7: 79.
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