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Cells 2018, 7(7), 79;

Chlamydomonas Basal Bodies as Flagella Organizing Centers

Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
Author to whom correspondence should be addressed.
Received: 12 June 2018 / Revised: 9 July 2018 / Accepted: 10 July 2018 / Published: 17 July 2018
(This article belongs to the Special Issue Comparative Biology of Centrosomal Structures in Eukaryotes)
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During ciliogenesis, centrioles convert to membrane-docked basal bodies, which initiate the formation of cilia/flagella and template the nine doublet microtubules of the flagellar axoneme. The discovery that many human diseases and developmental disorders result from defects in flagella has fueled a strong interest in the analysis of flagellar assembly. Here, we will review the structure, function, and development of basal bodies in the unicellular green alga Chlamydomonas reinhardtii, a widely used model for the analysis of basal bodies and flagella. Intraflagellar transport (IFT), a flagella-specific protein shuttle critical for ciliogenesis, was first described in C. reinhardtii. A focus of this review will be on the role of the basal bodies in organizing the IFT machinery. View Full-Text
Keywords: bld2; bld10; bld12; centrin; striated fiber assemblin (SFA); intraflagellar transport (IFT); axoneme; central pair; microtubules; centriole bld2; bld10; bld12; centrin; striated fiber assemblin (SFA); intraflagellar transport (IFT); axoneme; central pair; microtubules; centriole

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Wingfield, J.L.; Lechtreck, K.-F. Chlamydomonas Basal Bodies as Flagella Organizing Centers. Cells 2018, 7, 79.

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