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Cells 2018, 7(12), 236; https://doi.org/10.3390/cells7120236

Heparanase: A Multitasking Protein Involved in Extracellular Matrix (ECM) Remodeling and Intracellular Events

1
Department of Biomedical Sciences, University of Padova, Viale G. Colombo 3, 35121 Padova, Italy
2
Renal Unit, Department of Medicine, University of Verona, Piazzale Stefani 1, 37126 Verona, Italy
3
Maria Cecilia Hospital, GVM Care and Research, Via Corriera 1, 48033 Cotignola (Ravenna), Italy
*
Author to whom correspondence should be addressed.
Received: 6 October 2018 / Revised: 17 November 2018 / Accepted: 22 November 2018 / Published: 28 November 2018
(This article belongs to the Special Issue Extracellular Matrix Remodeling)
Full-Text   |   PDF [863 KB, uploaded 28 November 2018]   |  

Abstract

Heparanase (HPSE) has been defined as a multitasking protein that exhibits a peculiar enzymatic activity towards HS chains but which simultaneously performs other non-enzymatic functions. Through its enzymatic activity, HPSE catalyzes the cutting of the side chains of heparan sulfate (HS) proteoglycans, thus contributing to the remodeling of the extracellular matrix and of the basal membranes. Furthermore, thanks to this activity, HPSE also promotes the release and diffusion of various HS-linked molecules like growth factors, cytokines and enzymes. In addition to being an enzyme, HPSE has been shown to possess the ability to trigger different signaling pathways by interacting with transmembrane proteins. In normal tissue and in physiological conditions, HPSE exhibits only low levels of expression restricted only to keratinocytes, trophoblast, platelets and mast cells and leukocytes. On the contrary, in pathological conditions, such as in tumor progression and metastasis, inflammation and fibrosis, it is overexpressed. With this brief review, we intend to provide an update on the current knowledge about the different role of HPSE protein exerted by its enzymatic and non-enzymatic activity. View Full-Text
Keywords: heparanase; extracellular matrix (ECM) heparanase; extracellular matrix (ECM)
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Masola, V.; Bellin, G.; Gambaro, G.; Onisto, M. Heparanase: A Multitasking Protein Involved in Extracellular Matrix (ECM) Remodeling and Intracellular Events. Cells 2018, 7, 236.

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