Next Article in Journal
Epigenetic Erosion in Adult Stem Cells: Drivers and Passengers of Aging
Next Article in Special Issue
Effect of a Collagen-Based Compound on Morpho-Functional Properties of Cultured Human Tenocytes
Previous Article in Journal
SIRT-3 Modulation by Resveratrol Improves Mitochondrial Oxidative Phosphorylation in Diabetic Heart through Deacetylation of TFAM
Previous Article in Special Issue
Matrix Metalloproteinase-1 and Acid Phosphatase in the Degradation of the Lamina Propria of Eruptive Pathway of Rat Molars
Open AccessReview

Heparanase: A Multitasking Protein Involved in Extracellular Matrix (ECM) Remodeling and Intracellular Events

Department of Biomedical Sciences, University of Padova, Viale G. Colombo 3, 35121 Padova, Italy
Renal Unit, Department of Medicine, University of Verona, Piazzale Stefani 1, 37126 Verona, Italy
Maria Cecilia Hospital, GVM Care and Research, Via Corriera 1, 48033 Cotignola (Ravenna), Italy
Author to whom correspondence should be addressed.
Cells 2018, 7(12), 236;
Received: 6 October 2018 / Revised: 17 November 2018 / Accepted: 22 November 2018 / Published: 28 November 2018
(This article belongs to the Special Issue Extracellular Matrix Remodeling)
Heparanase (HPSE) has been defined as a multitasking protein that exhibits a peculiar enzymatic activity towards HS chains but which simultaneously performs other non-enzymatic functions. Through its enzymatic activity, HPSE catalyzes the cutting of the side chains of heparan sulfate (HS) proteoglycans, thus contributing to the remodeling of the extracellular matrix and of the basal membranes. Furthermore, thanks to this activity, HPSE also promotes the release and diffusion of various HS-linked molecules like growth factors, cytokines and enzymes. In addition to being an enzyme, HPSE has been shown to possess the ability to trigger different signaling pathways by interacting with transmembrane proteins. In normal tissue and in physiological conditions, HPSE exhibits only low levels of expression restricted only to keratinocytes, trophoblast, platelets and mast cells and leukocytes. On the contrary, in pathological conditions, such as in tumor progression and metastasis, inflammation and fibrosis, it is overexpressed. With this brief review, we intend to provide an update on the current knowledge about the different role of HPSE protein exerted by its enzymatic and non-enzymatic activity. View Full-Text
Keywords: heparanase; extracellular matrix (ECM) heparanase; extracellular matrix (ECM)
Show Figures

Figure 1

MDPI and ACS Style

Masola, V.; Bellin, G.; Gambaro, G.; Onisto, M. Heparanase: A Multitasking Protein Involved in Extracellular Matrix (ECM) Remodeling and Intracellular Events. Cells 2018, 7, 236.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop