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Cells 2018, 7(10), 152; https://doi.org/10.3390/cells7100152

Emerging Picture of Deuterosome-Dependent Centriole Amplification in MCCs

Department of Bioscience & Bioengineering, Indian Institute of Technology Jodhpur, NH 65, Nagour Road, Karwar 342037, India
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Received: 13 August 2018 / Revised: 20 September 2018 / Accepted: 25 September 2018 / Published: 27 September 2018
(This article belongs to the Special Issue Cilia and Flagella: Structure, Function and Beyond)
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Abstract

Multiciliated cells (MCCs) have several hair-like structures called cilia, which are required to propel substances on their surface. A cilium is organized from a basal body which resembles a hollow microtubule structure called a centriole. In terminally differentiated MCCs, hundreds of new basal bodies/centrioles are formed via two parallel pathways: the centriole- and deuterosome-dependent pathways. The deuterosome-dependent pathway is also referred to as “de novo” because unlike the centriole-dependent pathway which requires pre-existing centrioles, in the de novo pathway multiple new centrioles are organized around non-microtubule structures called deuterosomes. In the last five years, some deuterosome-specific markers have been identified and concurrent advancements in the super-resolution techniques have significantly contributed to gaining insights about the major stages of centriole amplification during ciliogenesis. Altogether, a new picture is emerging which also challenges the previous notion that deuterosome pathway is de novo. This review is primarily focused on studies that have contributed towards the better understanding of deuterosome-dependent centriole amplification and presents a developing model about the major stages identified during this process. View Full-Text
Keywords: cilia; centriole; deuterosome; multiciliated cells; basal body cilia; centriole; deuterosome; multiciliated cells; basal body
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Shahid, U.; Singh, P. Emerging Picture of Deuterosome-Dependent Centriole Amplification in MCCs. Cells 2018, 7, 152.

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