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Albumin and Furosemide Combination for Management of Edema in Nephrotic Syndrome: A Review of Clinical Studies

Department of Medicine, Rutgers New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
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Academic Editor: Christoph Englert
Cells 2015, 4(4), 622-630; https://doi.org/10.3390/cells4040622
Received: 7 August 2015 / Revised: 29 September 2015 / Accepted: 30 September 2015 / Published: 7 October 2015
(This article belongs to the Special Issue The Kidney: Development, Disease and Regeneration)
The treatment of edema in patients with nephrotic syndrome is generally managed by dietary sodium restriction and loop diuretics. However, edema does not improve in some patients despite adequate sodium restriction and maximal dose of diuretics. In such patients, combination of albumin and a loop diuretic may improve edema by diuresis and natriuresis. The response to this combination of albumin and a diuretic has not been observed in all studies. The purpose of this review is to discuss the physiology of diuresis and natriuresis of this combination therapy, and provide a brief summary of various studies that have used albumin and a loop diuretic to improve diuretic-resistant edema. Also, the review suggests various reasons for not observing similar results by various investigators. View Full-Text
Keywords: nephrotic syndrome; albumin and diuretic; diuresis; natriuresis; edema management nephrotic syndrome; albumin and diuretic; diuresis; natriuresis; edema management
MDPI and ACS Style

Duffy, M.; Jain, S.; Harrell, N.; Kothari, N.; Reddi, A.S. Albumin and Furosemide Combination for Management of Edema in Nephrotic Syndrome: A Review of Clinical Studies. Cells 2015, 4, 622-630. https://doi.org/10.3390/cells4040622

AMA Style

Duffy M, Jain S, Harrell N, Kothari N, Reddi AS. Albumin and Furosemide Combination for Management of Edema in Nephrotic Syndrome: A Review of Clinical Studies. Cells. 2015; 4(4):622-630. https://doi.org/10.3390/cells4040622

Chicago/Turabian Style

Duffy, Margaret, Shashank Jain, Nicholas Harrell, Neil Kothari, and Alluru S. Reddi 2015. "Albumin and Furosemide Combination for Management of Edema in Nephrotic Syndrome: A Review of Clinical Studies" Cells 4, no. 4: 622-630. https://doi.org/10.3390/cells4040622

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