Autophagy-Related Deubiquitinating Enzymes Involved in Health and Disease
Abstract
:1. Introduction
1.1. Autophagy
1.2. Deubiquitinating Enzymes
2. Deubiquitinating Enzymes Involved in Autophagy
2.1. A20
2.2. USP10 and USP13
2.3. USP33 and USP20
2.4. AMSH
2.5. USP8, USP15, USP30 and USP35
2.6. USP36
2.7. SseL
3. Conclusions
Deubiquitinase | DUB-type | Localization | Involvement in Autophagy 1 | Autophagy-related Target 1 | Effect on Autophagy | Disease Category 1,2 | Inhibitor 3 | References |
---|---|---|---|---|---|---|---|---|
A20 (TNFAIP3) | OTU | cytosol , lysosome |
|
| - - | Inflammation; Cancer? | [57,58,59,60,61,63,65,76] | |
AMSH | JAMM | endosome |
|
| + | Neuro-degeneration | [109,110,111] | |
SseL | bacterial DUB | cytosol |
|
| - | Bacterial infection | [173] | |
UCH-L1 | UCH | ER, cytosol, nucleus |
|
| - | Neuro-degeneration | LDN91946; Isa- tin O-acyloxime | [53,54,55] |
USP8 (UBPY) | USP | cytosol, endosome |
|
| + | Neuro-degeneration? | HBX 90,397; 9-E | [131,136,137,138] |
USP10 | USP | cytosol, nucleus |
|
| + - | Cancer | Spautin 1 | [79,82,83,89,91] |
USP13 | USP | cytosol, nucleus |
|
| + | Cancer | Spautin 1 | [79,82,83] |
USP15 | USP | mitochondrion |
|
| - | Neuro-degeneration | [139] | |
USP20 | USP | cytosol, cytoskeleton |
|
| - | Cancer | [102,105] | |
USP22 | USP | cytosol, nucleus |
|
| + | Cancer | [51] | |
USP30 | USP | mitochondrion |
|
| - | Neuro-degeneration | 15-oxospira-milactone(S3) | [140,141,143,145] |
USP33 | USP | cytosol, cytoskeleton, Golgi apparatus |
|
| + - | Cancer | [94,95,96,97,102] | |
USP35 | USP | mitochondrion |
|
| - | Neuro-degeneration | [141] | |
USP36 | USP | cytosol, nucleus |
|
| - | Cancer, Neuro-degeneration | [158,161,162] |
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Magraoui, F.E.; Reidick, C.; Meyer, H.E.; Platta, H.W. Autophagy-Related Deubiquitinating Enzymes Involved in Health and Disease. Cells 2015, 4, 596-621. https://doi.org/10.3390/cells4040596
Magraoui FE, Reidick C, Meyer HE, Platta HW. Autophagy-Related Deubiquitinating Enzymes Involved in Health and Disease. Cells. 2015; 4(4):596-621. https://doi.org/10.3390/cells4040596
Chicago/Turabian StyleMagraoui, Fouzi El, Christina Reidick, Hemut E. Meyer, and Harald W. Platta. 2015. "Autophagy-Related Deubiquitinating Enzymes Involved in Health and Disease" Cells 4, no. 4: 596-621. https://doi.org/10.3390/cells4040596