Non-Coding RNAs Including miRNAs and lncRNAs in Cardiovascular Biology and Disease
Abstract
:1. Introduction
2. miRNAs in Cardiac Development
3. Cardiac Regeneration Regulated by miRNAs
4. miRNAs in Cardiac Hypertrophy, Remodeling and Heart Failure
5. Cardiac Ischemia Regulated by miRNAs
6. miRNAs “Conducting” Arrhythmia
7. Diagnostic and Therapeutic Uses of miRNAs
microRNA | miRNA Targets | Function in the Heart | Reference(s) |
---|---|---|---|
miR-1 | RhoA, Cdc42, Nelf-A/WHSC2, Kcnj2, Gja1, Ppp2r5a, Vegfa | cardiac hypertrophy, arrythmia, reprogramming of fibroblasts into cardiomyocyte-like cells | [18,42,53,54] |
miR-15 | Chek1 | postnatal cardiomyocyte mitotic arrest | [11] |
miR-16 | Chek1 | postnatal cardiomyocyte mitotic arrest | [11] |
miR-19 | Pten | cardiomyocyte proliferation | [10] |
miR-21 | Ppara, Mpv17l, Sorbs2, Pdlim5, PDCD4 | ischemia/reperfusion, cardiac hypertrophy | [24,25,40] |
miR-22 | Sirt1, HDAC4, PPARα, Purb | cardiac hypertrophy | [28,29] |
miR-23 | MuRF1 | cardiac hypertrophy | [27] |
miR-25 | Serca2, Ip3r1 | arrythmia, heart failure | [55] |
miR-26 | KCNJ2 | arrythmia | [56] |
miR-29 | Col1a1, Col1a2, Col3a1, ELN | arrythmia, cardiac fibrosis | [34] |
miR-30 | CTGF | cardiac fibrosis | [33] |
miR-34 | PPP1R10, vinculin, Sema4b, Pofut1, Bcl6 | myocardial infarction, cardiac hypertrophy | [57,58] |
miR-132 | FoxO3 | cardiac hypertrophy | [59] |
miR-133 | CTGF | cardiac fibrosis, cardiac hypertrophy, cardiac remodeling, reprogramming of fibroblasts into cardiomyocyte-like cells | [18,33,47,54] |
miR-155 | Jarid2, Socs1 | cardiac hypertrophy, cardiac fibrosis | [30,31] |
miR-195 | Chek1 | postnatal cardiomyocyte mitotic arrest | [11] |
miR-199 | Dyrk1a | cardiac hypertrophy, cardiomyocyte proliferation | [9] |
miR-208 | Med13 | cardiac hypertrophy, reprogramming of fibroblasts into cardiomyocyte-like cells | [18] |
miR-212 | FoxO3 | cardiac hypertrophy | [59] |
miR-214 | Slc8a1, Bcl2l11, Ppif | cardiac remodeling | [60] |
miR-320 | Hsp6b | myocardial ischemia | [41] |
miR-328 | Cacna1c, Cacnb1 | atrial fibrillation | [61] |
miR-486 | Pten, Foxo1a | cardiac hypertrophy | [62] |
miR-497 | Chek1 | postnatal cardiomyocyte mitotic arrest | [11] |
miR-499 | Calcineurin, Drp1 | cardiac hypertrophy, reprogramming of fibroblasts into cardiomyocyte-like cells | [18,63] |
miR-590 | unknown | cardiomyocyte proliferation | [9] |
8. Long Non-Coding RNAs (LncRNAs) in Cardiac Development
9. lncRNAs in Cardiac Disease
10. lncRNAs as Competing Endogenous RNA
11. Future Prospects
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Kataoka, M.; Wang, D.-Z. Non-Coding RNAs Including miRNAs and lncRNAs in Cardiovascular Biology and Disease. Cells 2014, 3, 883-898. https://doi.org/10.3390/cells3030883
Kataoka M, Wang D-Z. Non-Coding RNAs Including miRNAs and lncRNAs in Cardiovascular Biology and Disease. Cells. 2014; 3(3):883-898. https://doi.org/10.3390/cells3030883
Chicago/Turabian StyleKataoka, Masaharu, and Da-Zhi Wang. 2014. "Non-Coding RNAs Including miRNAs and lncRNAs in Cardiovascular Biology and Disease" Cells 3, no. 3: 883-898. https://doi.org/10.3390/cells3030883