H3K27-Altered Diffuse Midline Glioma of the Brainstem: From Molecular Mechanisms to Targeted Interventions
Abstract
:1. Introduction
2. Mechanisms Driving Tumorigenesis of H3 K27-Altered DMG
3. Treatment Strategies in H3 K27-Altered DMG: Translational Advances and Challenges
4. Beyond Chemotherapy—Targeted Therapy in H3 K27-Altered DMG
4.1. Pathway Inhibitors
4.2. ONC201
4.3. Immunotherapies
5. Improving Intratumoral Drug Delivery in H3 K27-Altered DMG
5.1. Targeted Drug Delivery Systems
5.2. Nanoparticles
6. Future Directions
7. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Nonnenbroich, L.F.; Bouchal, S.M.; Millesi, E.; Rechberger, J.S.; Khatua, S.; Daniels, D.J. H3K27-Altered Diffuse Midline Glioma of the Brainstem: From Molecular Mechanisms to Targeted Interventions. Cells 2024, 13, 1122. https://doi.org/10.3390/cells13131122
Nonnenbroich LF, Bouchal SM, Millesi E, Rechberger JS, Khatua S, Daniels DJ. H3K27-Altered Diffuse Midline Glioma of the Brainstem: From Molecular Mechanisms to Targeted Interventions. Cells. 2024; 13(13):1122. https://doi.org/10.3390/cells13131122
Chicago/Turabian StyleNonnenbroich, Leo F., Samantha M. Bouchal, Elena Millesi, Julian S. Rechberger, Soumen Khatua, and David J. Daniels. 2024. "H3K27-Altered Diffuse Midline Glioma of the Brainstem: From Molecular Mechanisms to Targeted Interventions" Cells 13, no. 13: 1122. https://doi.org/10.3390/cells13131122
APA StyleNonnenbroich, L. F., Bouchal, S. M., Millesi, E., Rechberger, J. S., Khatua, S., & Daniels, D. J. (2024). H3K27-Altered Diffuse Midline Glioma of the Brainstem: From Molecular Mechanisms to Targeted Interventions. Cells, 13(13), 1122. https://doi.org/10.3390/cells13131122