Transcriptional Control of Subcutaneous Adipose Tissue by the Transcription Factor CTCF Modulates Heterogeneity in Fat Distribution in Women
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Leg Fat Mass Is Associated with Reduced Visceral Adipose Tissue and Healthier Clinical Profile in Premenopausal Women
3.2. CTCF Is a Key Factor Involved in Body Shape-Specific Transcriptional Regulation in Human ADSCs
3.3. Differential CTCF Enrichment in Apple vs. Pear ADSCs
3.4. Enrichment of CTCF at Active Transcription Start Site Containing YY1 Motifs Selectively in Pear ADSCs
3.5. Coordinated CTCF and RNAPII Binding at TSS of Genes Correlates with Body Shape-Specific Gene Expression
3.6. METRNL: A New CTCF Target Gene Associated with Differential Fat Distribution in Women
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
References
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Erdos, E.; Sandor, K.; Young-Erdos, C.L.; Halasz, L.; Smith, S.R.; Osborne, T.F.; Divoux, A. Transcriptional Control of Subcutaneous Adipose Tissue by the Transcription Factor CTCF Modulates Heterogeneity in Fat Distribution in Women. Cells 2024, 13, 86. https://doi.org/10.3390/cells13010086
Erdos E, Sandor K, Young-Erdos CL, Halasz L, Smith SR, Osborne TF, Divoux A. Transcriptional Control of Subcutaneous Adipose Tissue by the Transcription Factor CTCF Modulates Heterogeneity in Fat Distribution in Women. Cells. 2024; 13(1):86. https://doi.org/10.3390/cells13010086
Chicago/Turabian StyleErdos, Edina, Katalin Sandor, Crystal L. Young-Erdos, Laszlo Halasz, Steven R. Smith, Timothy F. Osborne, and Adeline Divoux. 2024. "Transcriptional Control of Subcutaneous Adipose Tissue by the Transcription Factor CTCF Modulates Heterogeneity in Fat Distribution in Women" Cells 13, no. 1: 86. https://doi.org/10.3390/cells13010086