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New Insights into the Mechanisms of Chaperon-Mediated Autophagy and Implications for Kidney Diseases

Pathology Department, The School of Medicine, Nankai University, 94 Weijin Road, Nankai District, Tianjin 300071, China
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Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Takahiro Seki
Cells 2022, 11(3), 406; https://doi.org/10.3390/cells11030406
Received: 24 December 2021 / Revised: 14 January 2022 / Accepted: 18 January 2022 / Published: 25 January 2022
(This article belongs to the Special Issue New Advance in Chaperone-Mediated Autophagy)
Chaperone-mediated autophagy (CMA) is a separate type of lysosomal proteolysis, characterized by its selectivity of substrate proteins and direct translocation into lysosomes. Recent studies have declared the involvement of CMA in a variety of physiologic and pathologic situations involving the kidney, and it has emerged as a potential target for the treatment of kidney diseases. The role of CMA in kidney diseases is context-dependent and appears reciprocally with macroautophagy. Among the renal resident cells, the proximal tubule exhibits a high basal level of CMA activity, and restoration of CMA alleviates the aging-related tubular alternations. The level of CMA is up-regulated under conditions of oxidative stress, such as in acute kidney injury, while it is declined in chronic kidney disease and aging-related kidney diseases, leading to the accumulation of oxidized substrates. Suppressed CMA leads to the kidney hypertrophy in diabetes mellitus, and the increase of CMA contributes to the progress and chemoresistance in renal cell carcinoma. With the progress on the understanding of the cellular functions and uncovering the clinical scenario, the application of targeting CMA in the treatment of kidney diseases is expected. View Full-Text
Keywords: chaperon-mediated autophagy; kidney diseases; lysosomal associated protein 2A; heat shock-cognate 71 kDa protein chaperon-mediated autophagy; kidney diseases; lysosomal associated protein 2A; heat shock-cognate 71 kDa protein
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MDPI and ACS Style

Yuan, Z.; Wang, S.; Tan, X.; Wang, D. New Insights into the Mechanisms of Chaperon-Mediated Autophagy and Implications for Kidney Diseases. Cells 2022, 11, 406. https://doi.org/10.3390/cells11030406

AMA Style

Yuan Z, Wang S, Tan X, Wang D. New Insights into the Mechanisms of Chaperon-Mediated Autophagy and Implications for Kidney Diseases. Cells. 2022; 11(3):406. https://doi.org/10.3390/cells11030406

Chicago/Turabian Style

Yuan, Zhen, Shuyuan Wang, Xiaoyue Tan, and Dekun Wang. 2022. "New Insights into the Mechanisms of Chaperon-Mediated Autophagy and Implications for Kidney Diseases" Cells 11, no. 3: 406. https://doi.org/10.3390/cells11030406

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