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Review

Buffering Adaptive Immunity by Hydrogen Sulfide

1
Anatomy Unit, Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43126 Parma, Italy
2
University Hospital of Parma, AOU-PR, Via Gramsci 14, 43126 Parma, Italy
3
Italian Foundation for the Research in Balneology, Via Po 22, 00198 Rome, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Alessandro Poggi
Cells 2022, 11(3), 325; https://doi.org/10.3390/cells11030325
Received: 29 December 2021 / Revised: 14 January 2022 / Accepted: 16 January 2022 / Published: 19 January 2022
(This article belongs to the Collection Feature Papers in ‘Cellular Immunology’)
T cell-mediated adaptive immunity is designed to respond to non-self antigens and pathogens through the activation and proliferation of various T cell populations. T helper 1 (Th1), Th2, Th17 and Treg cells finely orchestrate cellular responses through a plethora of paracrine and autocrine stimuli that include cytokines, autacoids, and hormones. Hydrogen sulfide (H2S) is one of these mediators able to induce/inhibit immunological responses, playing a role in inflammatory and autoimmune diseases, neurological disorders, asthma, acute pancreatitis, and sepsis. Both endogenous and exogenous H2S modulate numerous important cell signaling pathways. In monocytes, polymorphonuclear, and T cells H2S impacts on activation, survival, proliferation, polarization, adhesion pathways, and modulates cytokine production and sensitivity to chemokines. Here, we offer a comprehensive review on the role of H2S as a natural buffer able to maintain over time a functional balance between Th1, Th2, Th17 and Treg immunological responses. View Full-Text
Keywords: gasotransmitters; NaHS; cystathionine-synthase; cystathionine-lyase; sulphurous waters gasotransmitters; NaHS; cystathionine-synthase; cystathionine-lyase; sulphurous waters
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MDPI and ACS Style

Pozzi, G.; Gobbi, G.; Masselli, E.; Carubbi, C.; Presta, V.; Ambrosini, L.; Vitale, M.; Mirandola, P. Buffering Adaptive Immunity by Hydrogen Sulfide. Cells 2022, 11, 325. https://doi.org/10.3390/cells11030325

AMA Style

Pozzi G, Gobbi G, Masselli E, Carubbi C, Presta V, Ambrosini L, Vitale M, Mirandola P. Buffering Adaptive Immunity by Hydrogen Sulfide. Cells. 2022; 11(3):325. https://doi.org/10.3390/cells11030325

Chicago/Turabian Style

Pozzi, Giulia, Giuliana Gobbi, Elena Masselli, Cecilia Carubbi, Valentina Presta, Luca Ambrosini, Marco Vitale, and Prisco Mirandola. 2022. "Buffering Adaptive Immunity by Hydrogen Sulfide" Cells 11, no. 3: 325. https://doi.org/10.3390/cells11030325

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