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Buffering Adaptive Immunity by Hydrogen Sulfide

Anatomy Unit, Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43126 Parma, Italy
University Hospital of Parma, AOU-PR, Via Gramsci 14, 43126 Parma, Italy
Italian Foundation for the Research in Balneology, Via Po 22, 00198 Rome, Italy
Authors to whom correspondence should be addressed.
Academic Editor: Alessandro Poggi
Cells 2022, 11(3), 325;
Received: 29 December 2021 / Revised: 14 January 2022 / Accepted: 16 January 2022 / Published: 19 January 2022
(This article belongs to the Collection Feature Papers in ‘Cellular Immunology’)
T cell-mediated adaptive immunity is designed to respond to non-self antigens and pathogens through the activation and proliferation of various T cell populations. T helper 1 (Th1), Th2, Th17 and Treg cells finely orchestrate cellular responses through a plethora of paracrine and autocrine stimuli that include cytokines, autacoids, and hormones. Hydrogen sulfide (H2S) is one of these mediators able to induce/inhibit immunological responses, playing a role in inflammatory and autoimmune diseases, neurological disorders, asthma, acute pancreatitis, and sepsis. Both endogenous and exogenous H2S modulate numerous important cell signaling pathways. In monocytes, polymorphonuclear, and T cells H2S impacts on activation, survival, proliferation, polarization, adhesion pathways, and modulates cytokine production and sensitivity to chemokines. Here, we offer a comprehensive review on the role of H2S as a natural buffer able to maintain over time a functional balance between Th1, Th2, Th17 and Treg immunological responses. View Full-Text
Keywords: gasotransmitters; NaHS; cystathionine-synthase; cystathionine-lyase; sulphurous waters gasotransmitters; NaHS; cystathionine-synthase; cystathionine-lyase; sulphurous waters
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MDPI and ACS Style

Pozzi, G.; Gobbi, G.; Masselli, E.; Carubbi, C.; Presta, V.; Ambrosini, L.; Vitale, M.; Mirandola, P. Buffering Adaptive Immunity by Hydrogen Sulfide. Cells 2022, 11, 325.

AMA Style

Pozzi G, Gobbi G, Masselli E, Carubbi C, Presta V, Ambrosini L, Vitale M, Mirandola P. Buffering Adaptive Immunity by Hydrogen Sulfide. Cells. 2022; 11(3):325.

Chicago/Turabian Style

Pozzi, Giulia, Giuliana Gobbi, Elena Masselli, Cecilia Carubbi, Valentina Presta, Luca Ambrosini, Marco Vitale, and Prisco Mirandola. 2022. "Buffering Adaptive Immunity by Hydrogen Sulfide" Cells 11, no. 3: 325.

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