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Cells
Volume 11
Issue 23
10.3390/cells11233728
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Article

Identification and Validation of Glycosyltransferases Correlated with Cuproptosis as a Prognostic Model for Colon Adenocarcinoma

by
Wei Ma
,
Lingyuan Zhu
,
Shushu Song
*,
Bo Liu
* and
Jianxin Gu
NHC Key Laboratory of Glycoconjugates Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
*
Authors to whom correspondence should be addressed.
Cells 2022, 11(23), 3728; https://doi.org/10.3390/cells11233728
Submission received: 31 October 2022 / Revised: 14 November 2022 / Accepted: 18 November 2022 / Published: 22 November 2022
(This article belongs to the Special Issue Glycobiology in Cancer: From Molecular Mechanisms to Therapeutic Opportunities)
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Abstract

Cuproptosis is a newly defined programmed cell death pattern and is believed to play an important role in tumorigenesis and progression. In addition, many studies have shown that glycosylation modification is of vital importance in tumor progression. However, it remains unclear whether glycosyltransferases, the most critical enzymes involved in glycosylation modification, are associated with cuproptosis. In this study, we used bioinformatic methods to construct a signature of cuproptosis-related glycosyltransferases to predict the prognosis of colon adenocarcinoma patients. We found that cuproptosis was highly correlated with four glycosyltransferases in COAD, and our model predicted the prognosis of COAD patients. Further analysis of related functions revealed the possibility that cuproptosis-related glycosyltransferase Exostosin-like 2 (EXTL2) participated in tumor immunity.
Keywords: cuproptosis; glycosyltransferase; colon adenocarcinoma; prognosis; prediction cuproptosis; glycosyltransferase; colon adenocarcinoma; prognosis; prediction

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MDPI and ACS Style

Ma, W.; Zhu, L.; Song, S.; Liu, B.; Gu, J. Identification and Validation of Glycosyltransferases Correlated with Cuproptosis as a Prognostic Model for Colon Adenocarcinoma. Cells 2022, 11, 3728. https://doi.org/10.3390/cells11233728

AMA Style

Ma W, Zhu L, Song S, Liu B, Gu J. Identification and Validation of Glycosyltransferases Correlated with Cuproptosis as a Prognostic Model for Colon Adenocarcinoma. Cells. 2022; 11(23):3728. https://doi.org/10.3390/cells11233728

Chicago/Turabian Style

Ma, Wei, Lingyuan Zhu, Shushu Song, Bo Liu, and Jianxin Gu. 2022. "Identification and Validation of Glycosyltransferases Correlated with Cuproptosis as a Prognostic Model for Colon Adenocarcinoma" Cells 11, no. 23: 3728. https://doi.org/10.3390/cells11233728

APA Style

Ma, W., Zhu, L., Song, S., Liu, B., & Gu, J. (2022). Identification and Validation of Glycosyltransferases Correlated with Cuproptosis as a Prognostic Model for Colon Adenocarcinoma. Cells, 11(23), 3728. https://doi.org/10.3390/cells11233728

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