Accelerated Aging Characterizes the Early Stage of Alzheimer’s Disease
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Data Presentation and Statistical Analyses
3. Results
3.1. Total Power Is Reduced in Young AD and Old WT Mice
3.2. Power Imbalance in the Low Frequency Range Characterizes Young AD Mice
3.3. Impaired Coupling of SO to Higher Frequencies Is Shared between Young AD and Aged WT Mice
3.4. Defective SO Connectivity Anticipates the Aging Process in Young AD Mice
3.5. Imbalance in UP- and DOWN-States Marks AD Progression
3.6. Amyloidosis and Inflammation in AD and Aged WT Mice
4. Discussion
4.1. Specific Markers of Brain Changes in Young AD Mice
4.2. Premature Aging Also Characterizes the Brain Alterations in AD Mice
4.3. AD Mice Show More Brain Changes
4.4. Mechanistic Insights into Brain Network Alterations
4.5. Study Relevance
4.6. Study Limitations
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Leparulo, A.; Bisio, M.; Redolfi, N.; Pozzan, T.; Vassanelli, S.; Fasolato, C. Accelerated Aging Characterizes the Early Stage of Alzheimer’s Disease. Cells 2022, 11, 238. https://doi.org/10.3390/cells11020238
Leparulo A, Bisio M, Redolfi N, Pozzan T, Vassanelli S, Fasolato C. Accelerated Aging Characterizes the Early Stage of Alzheimer’s Disease. Cells. 2022; 11(2):238. https://doi.org/10.3390/cells11020238
Chicago/Turabian StyleLeparulo, Alessandro, Marta Bisio, Nelly Redolfi, Tullio Pozzan, Stefano Vassanelli, and Cristina Fasolato. 2022. "Accelerated Aging Characterizes the Early Stage of Alzheimer’s Disease" Cells 11, no. 2: 238. https://doi.org/10.3390/cells11020238