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Glutamate Signaling and Filopodiagenesis of Astrocytoma Cells in Brain Cancers: Survey and Questions

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Department of Biology, The University of British Columbia, Kelowna, BC V1V 1V7, Canada
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Department of Chemistry, The University of British Columbia, Kelowna, BC V1V 1V7, Canada
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Author to whom correspondence should be addressed.
Academic Editors: Bashayer Al Mubarak and Jing Qiu
Cells 2022, 11(17), 2657; https://doi.org/10.3390/cells11172657
Received: 18 May 2022 / Revised: 19 August 2022 / Accepted: 24 August 2022 / Published: 26 August 2022
(This article belongs to the Special Issue Glutamatergic Transmission: Role of Astrocytes in Health and Disease)
Astrocytes are non-excitable cells in the CNS that can cause life-threatening astrocytoma tumors when they transform to cancerous cells. Perturbed homeostasis of the neurotransmitter glutamate is associated with astrocytoma tumor onset and progression, but the factors that govern this phenomenon are less known. Herein, we review possible mechanisms by which glutamate may act in facilitating the growth of projections in astrocytic cells. This review discusses the similarities and differences between the morphology of astrocytes and astrocytoma cells, and the role that dysregulation in glutamate and calcium signaling plays in the aberrant morphology of astrocytoma cells. Converging reports suggest that ionotropic glutamate receptors and voltage-gated calcium channels expressed in astrocytes may be responsible for the abnormal filopodiagenesis or process extension leading to astrocytoma cells’ infiltration throughout the brain. View Full-Text
Keywords: astrocytes; astrocytoma; glutamate signaling; morphological response; filopodiagenesis astrocytes; astrocytoma; glutamate signaling; morphological response; filopodiagenesis
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MDPI and ACS Style

Tabatabaee, M.; Menard, F. Glutamate Signaling and Filopodiagenesis of Astrocytoma Cells in Brain Cancers: Survey and Questions. Cells 2022, 11, 2657. https://doi.org/10.3390/cells11172657

AMA Style

Tabatabaee M, Menard F. Glutamate Signaling and Filopodiagenesis of Astrocytoma Cells in Brain Cancers: Survey and Questions. Cells. 2022; 11(17):2657. https://doi.org/10.3390/cells11172657

Chicago/Turabian Style

Tabatabaee, Mitra, and Frederic Menard. 2022. "Glutamate Signaling and Filopodiagenesis of Astrocytoma Cells in Brain Cancers: Survey and Questions" Cells 11, no. 17: 2657. https://doi.org/10.3390/cells11172657

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