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Brief Report

Association of Clonal Hematopoiesis of Indeterminate Potential with Inflammatory Gene Expression in Patients with COPD

1
University of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Cardio-Pulmonary Institute (CPI), Justus Liebig University, 35392 Giessen, Germany
2
Max Planck Institute for Heart and Lung Research, DZL, CPI, 61231 Bad Nauheim, Germany
3
Department of Medicine, Hematology/Oncology, University Hospital Frankfurt, CPI, Goethe University, 60596 Frankfurt am Main, Germany
4
Frankfurt Cancer Institute (FCI), CPI, Goethe University, 60596 Frankfurt am Main, Germany
5
Institute for Lung Health (ILH), Justus Liebig University, 35392 Giessen, Germany
6
Institute for Neuropathology, CPI, Justus Liebig University, 35392 Giessen, Germany
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Institute of Vascular Signalling, Department of Molecular Medicine, CPI, Goethe University, 60596 Frankfurt am Main, Germany
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Department of Medicine, Pulmonary and Critical Care Medicine, Philipps University of Marburg, DZL, 35043 Marburg, Germany
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Department of Internal Medicine V-Pulmonology, Allergology and Critical Care Medicine, Saarland University, 66421 Homburg, Germany
10
Department of Medicine, Cardiology, CPI, Goethe University Hospital, 60596 Frankfurt am Main, Germany
11
Institute for Cardiovascular Regeneration, CPI, Goethe University, 60596 Frankfurt am Main, Germany
*
Author to whom correspondence should be addressed.
Academic Editors: Anindita Das and Arun Samidurai
Cells 2022, 11(13), 2121; https://doi.org/10.3390/cells11132121
Received: 11 May 2022 / Revised: 23 June 2022 / Accepted: 24 June 2022 / Published: 5 July 2022
Chronic obstructive pulmonary disease (COPD) is a disease with an inflammatory phenotype with increasing prevalence in the elderly. Expanded population of mutant blood cells carrying somatic mutations is termed clonal hematopoiesis of indeterminate potential (CHIP). The association between CHIP and COPD and its relevant effects on DNA methylation in aging are mainly unknown. Analyzing the deep-targeted amplicon sequencing from 125 COPD patients, we found enhanced incidence of CHIP mutations (~20%) with a predominance of DNMT3A CHIP-mediated hypomethylation of Phospholipase D Family Member 5 (PLD5), which in turn is positively correlated with increased levels of glycerol phosphocholine, pro-inflammatory cytokines, and deteriorating lung function. View Full-Text
Keywords: clonal hematopoiesis; inflammation; COPD clonal hematopoiesis; inflammation; COPD
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MDPI and ACS Style

Kuhnert, S.; Mansouri, S.; Rieger, M.A.; Savai, R.; Avci, E.; Díaz-Piña, G.; Padmasekar, M.; Looso, M.; Hadzic, S.; Acker, T.; Klatt, S.; Wilhelm, J.; Fleming, I.; Sommer, N.; Weissmann, N.; Vogelmeier, C.; Bals, R.; Zeiher, A.; Dimmeler, S.; Seeger, W.; Pullamsetti, S.S. Association of Clonal Hematopoiesis of Indeterminate Potential with Inflammatory Gene Expression in Patients with COPD. Cells 2022, 11, 2121. https://doi.org/10.3390/cells11132121

AMA Style

Kuhnert S, Mansouri S, Rieger MA, Savai R, Avci E, Díaz-Piña G, Padmasekar M, Looso M, Hadzic S, Acker T, Klatt S, Wilhelm J, Fleming I, Sommer N, Weissmann N, Vogelmeier C, Bals R, Zeiher A, Dimmeler S, Seeger W, Pullamsetti SS. Association of Clonal Hematopoiesis of Indeterminate Potential with Inflammatory Gene Expression in Patients with COPD. Cells. 2022; 11(13):2121. https://doi.org/10.3390/cells11132121

Chicago/Turabian Style

Kuhnert, Stefan, Siavash Mansouri, Michael A. Rieger, Rajkumar Savai, Edibe Avci, Gabriela Díaz-Piña, Manju Padmasekar, Mario Looso, Stefan Hadzic, Till Acker, Stephan Klatt, Jochen Wilhelm, Ingrid Fleming, Natascha Sommer, Norbert Weissmann, Claus Vogelmeier, Robert Bals, Andreas Zeiher, Stefanie Dimmeler, Werner Seeger, and Soni S. Pullamsetti. 2022. "Association of Clonal Hematopoiesis of Indeterminate Potential with Inflammatory Gene Expression in Patients with COPD" Cells 11, no. 13: 2121. https://doi.org/10.3390/cells11132121

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