Role of Cytoskeletal Diaphanous-Related Formins in Hearing Loss
Abstract
:1. Introduction
2. The Diaphanous Family
2.1. Evolution
2.2. Structure
2.3. Actin and Microtubule-Modulating Activity of Diaphanous Proteins
2.4. Expression of Diaphanous Proteins in the Inner Ear
3. DRF Mutations and Hearing Loss
3.1. DIAPH1
3.2. DIAPH2
3.3. DIAPH3
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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DIAPH1 | DIAPH3 | |
---|---|---|
Inheritance | AD | AD |
HL onset | First decade | Second decade 1 |
Affected frequencies | All | High frequencies more affected |
Progression | Yes | Yes |
ABR findings | Absent/abnormal | Absent/abnormal |
Middle ear reflexes | Present | Absent |
Affected structures | OHC | IHC, auditory nerve |
Other symptoms | May be accompanied by thrombocytopenia | None |
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Chiereghin, C.; Robusto, M.; Massa, V.; Castorina, P.; Ambrosetti, U.; Asselta, R.; Soldà, G. Role of Cytoskeletal Diaphanous-Related Formins in Hearing Loss. Cells 2022, 11, 1726. https://doi.org/10.3390/cells11111726
Chiereghin C, Robusto M, Massa V, Castorina P, Ambrosetti U, Asselta R, Soldà G. Role of Cytoskeletal Diaphanous-Related Formins in Hearing Loss. Cells. 2022; 11(11):1726. https://doi.org/10.3390/cells11111726
Chicago/Turabian StyleChiereghin, Chiara, Michela Robusto, Valentina Massa, Pierangela Castorina, Umberto Ambrosetti, Rosanna Asselta, and Giulia Soldà. 2022. "Role of Cytoskeletal Diaphanous-Related Formins in Hearing Loss" Cells 11, no. 11: 1726. https://doi.org/10.3390/cells11111726