Next Article in Journal
Circulating P2X7 Receptor Signaling Components as Diagnostic Biomarkers for Temporal Lobe Epilepsy
Previous Article in Journal
Establishment and Characterization of a Novel Gill Cell Line, LG-1, from Atlantic Lumpfish (Cyclopterus lumpus L.)
Review

Fibronectin: Molecular Structure, Fibrillar Structure and Mechanochemical Signaling

Department of Biomedical Engineering, Virginia Commonwealth University, 401 W. Main St., Richmond, VA 23284, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Wayne Carver
Cells 2021, 10(9), 2443; https://doi.org/10.3390/cells10092443
Received: 30 July 2021 / Revised: 9 September 2021 / Accepted: 10 September 2021 / Published: 16 September 2021
The extracellular matrix (ECM) plays a key role as both structural scaffold and regulator of cell signal transduction in tissues. In times of ECM assembly and turnover, cells upregulate assembly of the ECM protein, fibronectin (FN). FN is assembled by cells into viscoelastic fibrils that can bind upward of 40 distinct growth factors and cytokines. These fibrils play a key role in assembling a provisional ECM during embryonic development and wound healing. Fibril assembly is also often upregulated during disease states, including cancer and fibrotic diseases. FN fibrils have unique mechanical properties, which allow them to alter mechanotransduction signals sensed and relayed by cells. Binding of soluble growth factors to FN fibrils alters signal transduction from these proteins, while binding of other ECM proteins, including collagens, elastins, and proteoglycans, to FN fibrils facilitates the maturation and tissue specificity of the ECM. In this review, we will discuss the assembly of FN fibrils from individual FN molecules; the composition, structure, and mechanics of FN fibrils; the interaction of FN fibrils with other ECM proteins and growth factors; the role of FN in transmitting mechanobiology signaling events; and approaches for studying the mechanics of FN fibrils. View Full-Text
Keywords: fibronectin; fibrillogenesis; extracellular matrix; biomechanics; mechanobiology fibronectin; fibrillogenesis; extracellular matrix; biomechanics; mechanobiology
Show Figures

Figure 1

MDPI and ACS Style

Dalton, C.J.; Lemmon, C.A. Fibronectin: Molecular Structure, Fibrillar Structure and Mechanochemical Signaling. Cells 2021, 10, 2443. https://doi.org/10.3390/cells10092443

AMA Style

Dalton CJ, Lemmon CA. Fibronectin: Molecular Structure, Fibrillar Structure and Mechanochemical Signaling. Cells. 2021; 10(9):2443. https://doi.org/10.3390/cells10092443

Chicago/Turabian Style

Dalton, Caleb J., and Christopher A. Lemmon. 2021. "Fibronectin: Molecular Structure, Fibrillar Structure and Mechanochemical Signaling" Cells 10, no. 9: 2443. https://doi.org/10.3390/cells10092443

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop