Next Article in Journal
Role of Complement in Regulating Inflammation Processes in Renal and Prostate Cancers
Previous Article in Journal
Neuronal Dynamics and miRNA Signaling Differ between SH-SY5Y APPSwe and PSEN1 Mutant iPSC-Derived AD Models upon Modulation with miR-124 Mimic and Inhibitor
Systematic Review

Co-Expression Network Analysis of MicroRNAs and Proteins in Severe Traumatic Brain Injury: A Systematic Review

by 1, 1,2,3,* and 1,2,3,*
1
Neuroscience and Ophthalmology Group, Institute of Inflammation and Ageing, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
2
Centre for Trauma Sciences Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
3
Surgical Reconstruction and Microbiology Research Centre, National Institute for Health Research, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
*
Authors to whom correspondence should be addressed.
Academic Editor: Bonnie Firestein
Cells 2021, 10(9), 2425; https://doi.org/10.3390/cells10092425
Received: 16 August 2021 / Revised: 6 September 2021 / Accepted: 13 September 2021 / Published: 14 September 2021
Traumatic brain injury (TBI) represents one of the leading causes of mortality and morbidity worldwide, placing an enormous socioeconomic burden on healthcare services and communities around the world. Survivors of TBI can experience complications ranging from temporary neurological and psychosocial problems to long-term, severe disability and neurodegenerative disease. The current lack of therapeutic agents able to mitigate the effects of secondary brain injury highlights the urgent need for novel target discovery. This study comprises two independent systematic reviews, investigating both microRNA (miRNA) and proteomic expression in rat models of severe TBI (sTBI). The results were combined to perform integrated miRNA-protein co-expression analyses with the aim of uncovering the potential roles of miRNAs in sTBI and to ultimately identify new targets for therapy. Thirty-four studies were included in total. Bioinformatic analysis was performed to identify any miRNA–protein associations. Endocytosis and TNF signalling pathways were highlighted as common pathways involving both miRNAs and proteins found to be differentially expressed in rat brain tissue following sTBI, suggesting efforts to find novel therapeutic targets that should be focused here. Further high-quality investigations are required to ascertain the involvement of these pathways and their miRNAs in the pathogenesis of TBI and other CNS diseases and to therefore uncover those targets with the greatest therapeutic potential. View Full-Text
Keywords: traumatic brain injury; microRNAs; proteins; target discovery; bioinformatics traumatic brain injury; microRNAs; proteins; target discovery; bioinformatics
Show Figures

Figure 1

MDPI and ACS Style

Osgood, C.; Ahmed, Z.; Di Pietro, V. Co-Expression Network Analysis of MicroRNAs and Proteins in Severe Traumatic Brain Injury: A Systematic Review. Cells 2021, 10, 2425. https://doi.org/10.3390/cells10092425

AMA Style

Osgood C, Ahmed Z, Di Pietro V. Co-Expression Network Analysis of MicroRNAs and Proteins in Severe Traumatic Brain Injury: A Systematic Review. Cells. 2021; 10(9):2425. https://doi.org/10.3390/cells10092425

Chicago/Turabian Style

Osgood, Claire, Zubair Ahmed, and Valentina Di Pietro. 2021. "Co-Expression Network Analysis of MicroRNAs and Proteins in Severe Traumatic Brain Injury: A Systematic Review" Cells 10, no. 9: 2425. https://doi.org/10.3390/cells10092425

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop