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Translation Initiation Regulated by RNA-Binding Protein in Mammals: The Modulation of Translation Initiation Complex by Trans-Acting Factors

Department of Pharmacy, Kindai University, Kowakae 3-4-1, Higashi-Osaka City 577-8502, Japan
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Author to whom correspondence should be addressed.
Academic Editor: Atsufumi Kawabata
Cells 2021, 10(7), 1711; https://doi.org/10.3390/cells10071711
Received: 31 May 2021 / Revised: 3 July 2021 / Accepted: 4 July 2021 / Published: 6 July 2021
(This article belongs to the Special Issue Cell Biology: State-of-the-Art and Perspectives in Japan)
Protein synthesis is tightly regulated at each step of translation. In particular, the formation of the basic cap-binding complex, eukaryotic initiation factor 4F (eIF4F) complex, on the 5′ cap structure of mRNA is positioned as the rate-limiting step, and various cis-elements on mRNA contribute to fine-tune spatiotemporal protein expression. The cis-element on mRNAs is recognized and bound to the trans-acting factors, which enable the regulation of the translation rate or mRNA stability. In this review, we focus on the molecular mechanism of how the assembly of the eIF4F complex is regulated on the cap structure of mRNAs. We also summarize the fine-tuned regulation of translation initiation by various trans-acting factors through cis-elements on mRNAs. View Full-Text
Keywords: translation initiation; RNA-binding protein; microRNA; AU-rich element; poly(A)-binding protein; signaling pathway translation initiation; RNA-binding protein; microRNA; AU-rich element; poly(A)-binding protein; signaling pathway
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MDPI and ACS Style

Fukao, A.; Tomohiro, T.; Fujiwara, T. Translation Initiation Regulated by RNA-Binding Protein in Mammals: The Modulation of Translation Initiation Complex by Trans-Acting Factors. Cells 2021, 10, 1711. https://doi.org/10.3390/cells10071711

AMA Style

Fukao A, Tomohiro T, Fujiwara T. Translation Initiation Regulated by RNA-Binding Protein in Mammals: The Modulation of Translation Initiation Complex by Trans-Acting Factors. Cells. 2021; 10(7):1711. https://doi.org/10.3390/cells10071711

Chicago/Turabian Style

Fukao, Akira, Takumi Tomohiro, and Toshinobu Fujiwara. 2021. "Translation Initiation Regulated by RNA-Binding Protein in Mammals: The Modulation of Translation Initiation Complex by Trans-Acting Factors" Cells 10, no. 7: 1711. https://doi.org/10.3390/cells10071711

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