Next Article in Journal
PKA and PKC Balance in Synapse Elimination during Neuromuscular Junction Development
Next Article in Special Issue
Formation of Non-Nucleoplasmic Proteasome Foci during the Late Stage of Hyperosmotic Stress
Previous Article in Journal
TGF-β/Smad Signalling in Neurogenesis: Implications for Neuropsychiatric Diseases
Review

Ubiquitin-Conjugating Enzymes in Cancer

1
Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea
2
Lung Cancer Research Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea
3
Department of Physiology, College of Medicine, Gachon University, Incheon 21999, Korea
4
Department of Chemistry, Pukyong National University, Busan 48513, Korea
5
Division of Rheumatology, Department of Medicine, Seoul St. Mary’s Hospital, Catholic University, Seoul 06591, Korea
*
Authors to whom correspondence should be addressed.
Academic Editor: Kwon-Yul Ryu
Cells 2021, 10(6), 1383; https://doi.org/10.3390/cells10061383
Received: 6 May 2021 / Revised: 28 May 2021 / Accepted: 30 May 2021 / Published: 4 June 2021
(This article belongs to the Special Issue Role of Ubiquitin in Cellular Quality Control)
The ubiquitin-mediated degradation system is responsible for controlling various tumor-promoting processes, including DNA repair, cell cycle arrest, cell proliferation, apoptosis, angiogenesis, migration and invasion, metastasis, and drug resistance. The conjugation of ubiquitin to a target protein is mediated sequentially by the E1 (activating)‒E2 (conjugating)‒E3 (ligating) enzyme cascade. Thus, E2 enzymes act as the central players in the ubiquitination system, modulating various pathophysiological processes in the tumor microenvironment. In this review, we summarize the types and functions of E2s in various types of cancer and discuss the possibility of E2s as targets of anticancer therapeutic strategies. View Full-Text
Keywords: ubiquitin-conjugating enzyme; cancer; ubiquitination ubiquitin-conjugating enzyme; cancer; ubiquitination
Show Figures

Figure 1

MDPI and ACS Style

Bui, Q.T.; Hong, J.H.; Kwak, M.; Lee, J.Y.; Lee, P.C.-W. Ubiquitin-Conjugating Enzymes in Cancer. Cells 2021, 10, 1383. https://doi.org/10.3390/cells10061383

AMA Style

Bui QT, Hong JH, Kwak M, Lee JY, Lee PC-W. Ubiquitin-Conjugating Enzymes in Cancer. Cells. 2021; 10(6):1383. https://doi.org/10.3390/cells10061383

Chicago/Turabian Style

Bui, Quyen T., Jeong H. Hong, Minseok Kwak, Ji Y. Lee, and Peter C.-W. Lee. 2021. "Ubiquitin-Conjugating Enzymes in Cancer" Cells 10, no. 6: 1383. https://doi.org/10.3390/cells10061383

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop