Effect of Hydrocortisone on Angiotensinogen (AGT) Mutation–Causing Autosomal Recessive Renal Tubular Dysgenesis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Index Case
2.2. Construction of Plasmids
2.3. Cell Culture, Transfection and Protein Stability Assay
2.4. Western Blotting
2.5. Proximity Ligation Assay (PLA)
2.6. Luciferase Reporter Analysis of Glucocorticoid Receptor (GR)-Dependent Transactivation
2.7. Statistical Analysis
3. Results
3.1. In Vitro Expression of Truncated AGT
3.2. Measurement of Renin-AGT Interaction in Kidney
3.3. Effect of Hydrocortisone on the Expression of AGT in Liver
3.4. Effect of Hydrocortisone on the Interaction between Renin and Mutant AGT in Liver
3.5. Mutant AGT Impaired the Glucocorticoid Receptor (GR)-Dependent Transactivation
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Tseng, M.-H.; Huang, S.-M.; Konrad, M.; Huang, J.-L.; Shaw, S.W.; Tian, Y.-C.; Chueh, H.-Y.; Fan, W.-L.; Wu, T.-W.; Ding, J.-J.; et al. Effect of Hydrocortisone on Angiotensinogen (AGT) Mutation–Causing Autosomal Recessive Renal Tubular Dysgenesis. Cells 2021, 10, 782. https://doi.org/10.3390/cells10040782
Tseng M-H, Huang S-M, Konrad M, Huang J-L, Shaw SW, Tian Y-C, Chueh H-Y, Fan W-L, Wu T-W, Ding J-J, et al. Effect of Hydrocortisone on Angiotensinogen (AGT) Mutation–Causing Autosomal Recessive Renal Tubular Dysgenesis. Cells. 2021; 10(4):782. https://doi.org/10.3390/cells10040782
Chicago/Turabian StyleTseng, Min-Hua, Shih-Ming Huang, Martin Konrad, Jing-Long Huang, Steven W. Shaw, Ya-Chung Tian, Ho-Yen Chueh, Wen-Lang Fan, Tai-Wei Wu, Jhao-Jhuang Ding, and et al. 2021. "Effect of Hydrocortisone on Angiotensinogen (AGT) Mutation–Causing Autosomal Recessive Renal Tubular Dysgenesis" Cells 10, no. 4: 782. https://doi.org/10.3390/cells10040782
APA StyleTseng, M.-H., Huang, S.-M., Konrad, M., Huang, J.-L., Shaw, S. W., Tian, Y.-C., Chueh, H.-Y., Fan, W.-L., Wu, T.-W., Ding, J.-J., Chiang, M.-C., & Lin, S.-H. (2021). Effect of Hydrocortisone on Angiotensinogen (AGT) Mutation–Causing Autosomal Recessive Renal Tubular Dysgenesis. Cells, 10(4), 782. https://doi.org/10.3390/cells10040782