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Review

Cardiac Cell Therapy for Heart Repair: Should the Cells Be Left Out?

by 1,2 and 1,2,*
1
Department of Molecular Biomedical Sciences and Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA
2
Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill & North Carolina State University, Raleigh, NC 27607, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Raj Kishore and Alexander E. Kalyuzhny
Cells 2021, 10(3), 641; https://doi.org/10.3390/cells10030641
Received: 31 December 2020 / Revised: 25 February 2021 / Accepted: 10 March 2021 / Published: 13 March 2021
Cardiovascular disease (CVD) is still the leading cause of death worldwide. Coronary artery occlusion, or myocardial infarction (MI) causes massive loss of cardiomyocytes. The ischemia area is eventually replaced by a fibrotic scar. From the mechanical dysfunctions of the scar in electronic transduction, contraction and compliance, pathological cardiac dilation and heart failure develops. Once end-stage heart failure occurs, the only option is to perform heart transplantation. The sequential changes are termed cardiac remodeling, and are due to the lack of endogenous regenerative actions in the adult human heart. Regenerative medicine and biomedical engineering strategies have been pursued to repair the damaged heart and to restore normal cardiac function. Such strategies include both cellular and acellular products, in combination with biomaterials. In addition, substantial progress has been made to elucidate the molecular and cellular mechanisms underlying heart repair and regeneration. In this review, we summarize and discuss current therapeutic approaches for cardiac repair and provide a perspective on novel strategies that holding potential opportunities for future research and clinical translation. View Full-Text
Keywords: stem cell; myocardial infarction; cardiovascular diseases; acellular therapy; exosomes; paracrine effects; biomedical engineering; biomaterials stem cell; myocardial infarction; cardiovascular diseases; acellular therapy; exosomes; paracrine effects; biomedical engineering; biomaterials
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MDPI and ACS Style

Zhu, D.; Cheng, K. Cardiac Cell Therapy for Heart Repair: Should the Cells Be Left Out? Cells 2021, 10, 641. https://doi.org/10.3390/cells10030641

AMA Style

Zhu D, Cheng K. Cardiac Cell Therapy for Heart Repair: Should the Cells Be Left Out? Cells. 2021; 10(3):641. https://doi.org/10.3390/cells10030641

Chicago/Turabian Style

Zhu, Dashuai, and Ke Cheng. 2021. "Cardiac Cell Therapy for Heart Repair: Should the Cells Be Left Out?" Cells 10, no. 3: 641. https://doi.org/10.3390/cells10030641

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