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Open AccessReview

Nurse-Like Cells and Chronic Lymphocytic Leukemia B Cells: A Mutualistic Crosstalk inside Tissue Microenvironments

1
Department of Medical and Surgical Sciences, Section of Hematology, University of Modena and Reggio Emilia, 41124 Modena, Italy
2
Hematology Unit, Department of Oncology and Hematology, A.O.U of Modena, Policlinico, 41124 Modena, Italy
*
Authors to whom correspondence should be addressed.
Academic Editors: Loredana Moro and Lara Gibellini
Cells 2021, 10(2), 217; https://doi.org/10.3390/cells10020217
Received: 15 December 2020 / Revised: 15 January 2021 / Accepted: 18 January 2021 / Published: 22 January 2021
(This article belongs to the Special Issue Programmed Cell Death in Health and Disease)
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western countries and is an example of hematological disease where cooperation between genetic defects and tumor microenvironmental interaction is involved in pathogenesis. CLL is a disease that is considered as “addicted to the host”; indeed, the crosstalk between leukemic cells and the tumor microenvironment is essential for leukemic clone maintenance supporting CLL cells’ survival, proliferation, and protection from drug-induced apoptosis. CLL cells are not innocent bystanders but actively model and manipulate the surrounding microenvironment to their own advantage. Besides the different players involved in this crosstalk, nurse-like cells (NLC) resemble features related to leukemia-associated macrophages with an important function in preserving CLL cell survival and supporting an immunosuppressive microenvironment. This review provides a comprehensive overview of the role played by NLC in creating a nurturing and permissive milieu for CLL cells, illustrating the therapeutic possibilities in order to specifically target and re-educate them. View Full-Text
Keywords: CLL; microenvironment; nurse-like cells CLL; microenvironment; nurse-like cells
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MDPI and ACS Style

Fiorcari, S.; Maffei, R.; Atene, C.G.; Potenza, L.; Luppi, M.; Marasca, R. Nurse-Like Cells and Chronic Lymphocytic Leukemia B Cells: A Mutualistic Crosstalk inside Tissue Microenvironments. Cells 2021, 10, 217. https://doi.org/10.3390/cells10020217

AMA Style

Fiorcari S, Maffei R, Atene CG, Potenza L, Luppi M, Marasca R. Nurse-Like Cells and Chronic Lymphocytic Leukemia B Cells: A Mutualistic Crosstalk inside Tissue Microenvironments. Cells. 2021; 10(2):217. https://doi.org/10.3390/cells10020217

Chicago/Turabian Style

Fiorcari, Stefania; Maffei, Rossana; Atene, Claudio G.; Potenza, Leonardo; Luppi, Mario; Marasca, Roberto. 2021. "Nurse-Like Cells and Chronic Lymphocytic Leukemia B Cells: A Mutualistic Crosstalk inside Tissue Microenvironments" Cells 10, no. 2: 217. https://doi.org/10.3390/cells10020217

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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